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• W2076301035 endingPage "e61773" @default.
• W2076301035 startingPage "e61773" @default.
• W2076301035 abstract "After injury to the animal epidermis, a variety of genes are transcriptionally activated in nearby cells to regenerate the missing cells and facilitate barrier repair. The range and types of diffusible wound signals that are produced by damaged epidermis and function to activate repair genes during epidermal regeneration remains a subject of very active study in many animals. In Drosophila embryos, we have discovered that serine protease function is locally activated around wound sites, and is also required for localized activation of epidermal repair genes. The serine protease trypsin is sufficient to induce a striking global epidermal wound response without inflicting cell death or compromising the integrity of the epithelial barrier. We developed a trypsin wounding treatment as an amplification tool to more fully understand the changes in the Drosophila transcriptome that occur after epidermal injury. By comparing our array results with similar results on mammalian skin wounding we can see which evolutionarily conserved pathways are activated after epidermal wounding in very diverse animals. Our innovative serine protease-mediated wounding protocol allowed us to identify 8 additional genes that are activated in epidermal cells in the immediate vicinity of puncture wounds, and the functions of many of these genes suggest novel genetic pathways that may control epidermal wound repair. Additionally, our data augments the evidence that clean puncture wounding can mount a powerful innate immune transcriptional response, with different innate immune genes being activated in an interesting variety of ways. These include puncture-induced activation only in epidermal cells in the immediate vicinity of wounds, or in all epidermal cells, or specifically in the fat body, or in multiple tissues." @default.
• W2076301035 created "2016-06-24" @default.
• W2076301035 creator A5016505833 @default.
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• W2076301035 creator A5068651761 @default.
• W2076301035 creator A5080940430 @default.
• W2076301035 date "2013-04-24" @default.
• W2076301035 modified "2023-10-01" @default.
• W2076301035 title "Serine Proteolytic Pathway Activation Reveals an Expanded Ensemble of Wound Response Genes in Drosophila" @default.
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• W2076301035 doi "https://doi.org/10.1371/journal.pone.0061773" @default.
• W2076301035 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3634835" @default.
• W2076301035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23637905" @default.
• W2076301035 hasPublicationYear "2013" @default.
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