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- W2076304265 endingPage "1016" @default.
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- W2076304265 abstract "Protein Phosphatase 2A (PP2A) has a heterotrimeric-subunit structure,consisting of a core dimer of ∼36 kDa catalytic and ∼65 kDa scaffold subunits complexed to a third variable regulatory subunit. Several studies have implicated PP2A in Wg/Wnt signaling. However, reports on the precise nature of PP2A role in Wg/Wnt pathway in different organisms are conflicting. We show that twins (tws), which codes for the B/PR55 regulatory subunit of PP2A in Drosophila, is a positive regulator of Wg/Wnt signaling. In tws- wing discs both short- and long-range targets of Wingless morphogen are downregulated. Analyses of tws- mitotic clones suggest that requirement of Tws in Wingless pathway is cell-autonomous. Epistatic genetic studies indicate that Tws functions downstream of Dishevelled and upstream of Sgg and Armadillo. Our results suggest that Tws is required for the stabilization of Armadillo/β-catenin in response to Wg/Wnt signaling. Interestingly,overexpression of, otherwise normal, Tws protein induce dominant-negative phenotypes. The conflicting reports on the role of PP2A in Wg/Wnt signaling could be due to the dominant-negative effect caused by the overexpression of one of the subunits." @default.
- W2076304265 created "2016-06-24" @default.
- W2076304265 creator A5020962988 @default.
- W2076304265 creator A5026479487 @default.
- W2076304265 creator A5053235079 @default.
- W2076304265 creator A5063768867 @default.
- W2076304265 date "2004-03-01" @default.
- W2076304265 modified "2023-09-27" @default.
- W2076304265 title "<i>Drosophila</i>Twins regulates Armadillo levels in response to Wg/Wnt signal" @default.
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- W2076304265 doi "https://doi.org/10.1242/dev.00980" @default.
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