FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076304285> ?p ?o ?g. }

• W2076304285 endingPage "330" @default.
• W2076304285 startingPage "323" @default.
• W2076304285 abstract "Human corneal fibroblasts (HCF) inhibit T cell alloresponse in mixed leukocyte response-human corneal fibroblast coculture. The inhibition is contact independent, insensitive to indomethacin, and is enhanced by pretreatment of HCF with interferon-γ (IFN-γ). To investigate cytokine-dependent mechanisms of inhibition of T cell alloresponse by HCF, the capacity of cultured HCF to produce transforming growth factor-β (TGF-β) and the modulatory role of IFN-γ on their TGF-β production were investigated by radioreceptor binding inhibition assay (RRA) and the standard mink cell bioassay (BIA). The net total TGF-β concentration of 4 day culture supernatants from IFN-γ-treated HCF, measured by RRA, was 11.5 ng/ml. The net total bioactive TGF-β concentrations of 4 day culture supernatants from HCF, before and after treatment with IFN-γ, measured by BIA, were 2.0 and 4.8 ng/ml, respectively. These findings indicate that HCF produce TGF-β and increase their TGF-β output under the influence of the proinflammatory cytokine IFN-γ. Media-borne TGF-β binding proteins appeared to be primarily responsible for the discrepancy between the TGF-β values measured by RRA and BIA. Active exclusion of TGF-β binding proteins from intraocular fluids may have an important role in the maintenance of TGF-β-dependent ocular immune privilege. Corneal fibroblasts may utilize TGF-β--dependent mechanisms to maintain the immunosecluded environment of the cornea and to preserve the homeostasis of corneal optical competency. Interferon-γ may enhance corneal immunoseclusion by upregulating the TGF-β output of the corneal fibroblasts." @default.
• W2076304285 created "2016-06-24" @default.
• W2076304285 creator A5030355815 @default.
• W2076304285 creator A5032384814 @default.
• W2076304285 creator A5036303423 @default.
• W2076304285 creator A5046455836 @default.
• W2076304285 date "1995-04-01" @default.
• W2076304285 modified "2023-09-25" @default.
• W2076304285 title "Effect of Interferon-γ on the Expression of Transforming Growth Factor-β by Human Corneal Fibroblasts: Role in Corneal Immunoseclusion" @default.
• W2076304285 cites W1167613633 @default.
• W2076304285 cites W1503388237 @default.
• W2076304285 cites W1510408074 @default.
• W2076304285 cites W1510586846 @default.
• W2076304285 cites W1959521819 @default.
• W2076304285 cites W1968577782 @default.
• W2076304285 cites W1971871612 @default.
• W2076304285 cites W1977439384 @default.
• W2076304285 cites W1990548663 @default.
• W2076304285 cites W1995924810 @default.
• W2076304285 cites W2022782294 @default.
• W2076304285 cites W2025042164 @default.
• W2076304285 cites W2026499192 @default.
• W2076304285 cites W2029148411 @default.
• W2076304285 cites W2033848534 @default.
• W2076304285 cites W2035819392 @default.
• W2076304285 cites W2042524276 @default.
• W2076304285 cites W2045429561 @default.
• W2076304285 cites W2047951425 @default.
• W2076304285 cites W2062199188 @default.
• W2076304285 cites W2079135245 @default.
• W2076304285 cites W2085988850 @default.
• W2076304285 cites W2092816357 @default.
• W2076304285 cites W2093274847 @default.
• W2076304285 cites W2095919164 @default.
• W2076304285 cites W2099985524 @default.
• W2076304285 cites W2105990639 @default.
• W2076304285 cites W2156460034 @default.
• W2076304285 cites W2165894588 @default.
• W2076304285 cites W2320174780 @default.
• W2076304285 doi "https://doi.org/10.1089/jir.1995.15.323" @default.
• W2076304285 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7627807" @default.
• W2076304285 hasPublicationYear "1995" @default.
• W2076304285 type Work @default.
• W2076304285 sameAs 2076304285 @default.
• W2076304285 citedByCount "9" @default.
• W2076304285 countsByYear W20763042852013 @default.
• W2076304285 countsByYear W20763042852014 @default.
• W2076304285 countsByYear W20763042852021 @default.
• W2076304285 countsByYear W20763042852022 @default.
• W2076304285 crossrefType "journal-article" @default.
• W2076304285 hasAuthorship W2076304285A5030355815 @default.
• W2076304285 hasAuthorship W2076304285A5032384814 @default.
• W2076304285 hasAuthorship W2076304285A5036303423 @default.
• W2076304285 hasAuthorship W2076304285A5046455836 @default.
• W2076304285 hasConcept C118131993 @default.
• W2076304285 hasConcept C153911025 @default.
• W2076304285 hasConcept C169760540 @default.
• W2076304285 hasConcept C185592680 @default.
• W2076304285 hasConcept C203014093 @default.
• W2076304285 hasConcept C2776178377 @default.
• W2076304285 hasConcept C2776882836 @default.
• W2076304285 hasConcept C2778690821 @default.
• W2076304285 hasConcept C2781185574 @default.
• W2076304285 hasConcept C54355233 @default.
• W2076304285 hasConcept C81885089 @default.
• W2076304285 hasConcept C86803240 @default.
• W2076304285 hasConcept C8891405 @default.
• W2076304285 hasConcept C95444343 @default.
• W2076304285 hasConceptScore W2076304285C118131993 @default.
• W2076304285 hasConceptScore W2076304285C153911025 @default.
• W2076304285 hasConceptScore W2076304285C169760540 @default.
• W2076304285 hasConceptScore W2076304285C185592680 @default.
• W2076304285 hasConceptScore W2076304285C203014093 @default.
• W2076304285 hasConceptScore W2076304285C2776178377 @default.
• W2076304285 hasConceptScore W2076304285C2776882836 @default.
• W2076304285 hasConceptScore W2076304285C2778690821 @default.
• W2076304285 hasConceptScore W2076304285C2781185574 @default.
• W2076304285 hasConceptScore W2076304285C54355233 @default.
• W2076304285 hasConceptScore W2076304285C81885089 @default.
• W2076304285 hasConceptScore W2076304285C86803240 @default.
• W2076304285 hasConceptScore W2076304285C8891405 @default.
• W2076304285 hasConceptScore W2076304285C95444343 @default.
• W2076304285 hasIssue "4" @default.
• W2076304285 hasLocation W20763042851 @default.
• W2076304285 hasLocation W20763042852 @default.
• W2076304285 hasOpenAccess W2076304285 @default.
• W2076304285 hasPrimaryLocation W20763042851 @default.
• W2076304285 hasRelatedWork W1582706141 @default.
• W2076304285 hasRelatedWork W181678093 @default.
• W2076304285 hasRelatedWork W2005666125 @default.
• W2076304285 hasRelatedWork W2047209980 @default.
• W2076304285 hasRelatedWork W2069321762 @default.
• W2076304285 hasRelatedWork W2096367348 @default.
• W2076304285 hasRelatedWork W2321871323 @default.
• W2076304285 hasRelatedWork W3138050922 @default.
• W2076304285 hasRelatedWork W2185732136 @default.
• W2076304285 hasRelatedWork W2396811992 @default.
• W2076304285 hasVolume "15" @default.

• next