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- W2076307155 abstract "BACKGROUND : Nowadays, the collection of PBPCs by apheresis from healthy donors is a routine method. The mobilization with rHu G–CSF and the apheresis procedures are usually well tolerated without severe side effects. STUDY DESIGN AND METHODS : We report a severe complication in a 41‐year‐old unrelated female donor who was allowed to donate PBPCs and was mobilized with 10 μg of G–CSF per kg per day. During PBPC apheresis, she experienced a circulatory arrest after 132 minutes and processing of 7078 mL of blood (twice the donor's blood volume). RESULTS : Immediate cardiopulmonary resuscitation restored sinus rhythm and regulatory respiration without sequelae. Subsequent cardiologic examinations (heart catheterization, electrophysiologic testing, tilting table test) resulted in the diagnosis of a neurocardiogenic syncope. Other cardiac or circulatory disorders could be excluded. The implantation of a cardiac pacemaker was recommended to the donor. The 4‐year‐old recipient was successfully transplanted with the partial product collected until the arrest occurred. The patient received a total of 2.54 × 10 6 CD34+ cells per kg of body weight. CONCLUSION : After exclusion of other cardiac diseases, the diagnosed neurocardiogenic syncope probably induced the circulatory arrest during apheresis rather than the administration of G–CSF." @default.
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- W2076307155 date "2003-05-21" @default.
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- W2076307155 title "Circulatory arrest during PBPC apheresis in an unrelated donor" @default.
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- W2076307155 doi "https://doi.org/10.1046/j.1537-2995.2003.00400.x" @default.
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