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• W2076307303 abstract "Dystrophic skeletal muscle cells from Duchenne muscular dystrophy (DMD) patients and mdx mice exhibit elevated cytosolic Ca 2+ concentrations ([Ca 2+ ] c ). Pretreatment of mdx myotubes for 6–12 days with creatine (20 mM) decreased the elevation in [Ca 2+ ] c induced by either high extracellular Ca 2+ concentrations or hypo‐osmotic stress to control levels. 45 Ca 2+ influx measurements suggest that creatine lowered [Ca 2+ ] c by stimulating sarcoplasmic reticulum Ca 2+ ‐ATPase. Creatine pretreatment increased levels of phosphocreatine but not ATP. Furthermore, myotube formation and survival were significantly enhanced by creatine pretreatment. Therefore, creatine supplementation may be useful for treatment of DMD." @default.
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• W2076307303 date "1998-11-20" @default.
• W2076307303 modified "2023-10-13" @default.
• W2076307303 title "Creatine supplementation improves intracellular Ca²⁺ handling and survival in <i>mdx</i> skeletal muscle cells" @default.
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• W2076307303 doi "https://doi.org/10.1016/s0014-5793(98)01399-4" @default.
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