FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076307580> ?p ?o ?g. }

• W2076307580 endingPage "428" @default.
• W2076307580 startingPage "423" @default.
• W2076307580 abstract "The rate of immunological deterioration and progression to AIDS differs markedly between HIV-positive individuals, and may be influenced by cofactors, HIV phenotype and host T-cell response. Tumour necrosis factor (TNF)-alpha and lymphotoxin stimulate HIV replication and may induce apoptosis of HIV-infected and uninfected lymphocytes in vitro, thus accelerating disease progression and CD4 depletion. Variability in TNF production between individuals is to a degree genetically determined and may be predicted from polymorphisms of microsatellite regions surrounding the human TNF gene locus.We examined TNf microsatellite polymorphisms in 24 HIV-positive patients with slower disease progression (CD4 count > 400 x 10(6)/l at > or = 6 years), 20 HIV-positive patients with faster progression (CD4 count < 200 x 10(6)/l within 5 years) and 109 healthy controls resident in north-west England. Typing was performed by polymerase chain reaction amplification of TNF a, b, c and d microsatellites and alleles were defined using fluorescence-based semi-automated microsatellite mapping techniques.No significant differences in TNF a, b and d allele frequencies were observed between faster and slower progressors, or with healthy controls. The frequency of the TNF c2 allele was significantly different between HIV-positive slower (60.9%) and faster (15%) progressors (P = 0.002) with an odds ratio of 0.1 (95% confidence interval, 0-0.6). TNF c2 was also less frequent in faster progressors than in healthy controls (45.9%, P = 0.006) with an odds ratio of 0.2 (95% confidence interval 0-0.8).This is the first report demonstrating a strong association between the TNF c2 allele and the rate of HIV progression. Although it is possible that this finding may have arisen as a result of linkage disequilibrium with other alleles within the major histocompatibility complex that exert a more powerful effect upon progression, evidence is mounting to suggest that both TNF-alpha and lymphotoxin are closely involved in HIV disease progression and CD4 depletion. Our results serve to highlight the potential importance of genetic polymorphism, particularly of the TNF locus, in influencing the progression of HIV infection." @default.
• W2076307580 created "2016-06-24" @default.
• W2076307580 creator A5006784170 @default.
• W2076307580 creator A5010330353 @default.
• W2076307580 creator A5016596102 @default.
• W2076307580 creator A5028653219 @default.
• W2076307580 creator A5039566477 @default.
• W2076307580 creator A5041365930 @default.
• W2076307580 creator A5072132268 @default.
• W2076307580 creator A5080467252 @default.
• W2076307580 date "1997-03-01" @default.
• W2076307580 modified "2023-10-18" @default.
• W2076307580 title "Tumour necrosis factor c2 microsatellite allele is associated with the rate of HIV disease progression" @default.
• W2076307580 cites W1972428164 @default.
• W2076307580 cites W1974393084 @default.
• W2076307580 cites W1975374574 @default.
• W2076307580 cites W1976466060 @default.
• W2076307580 cites W1992256266 @default.
• W2076307580 cites W2011630381 @default.
• W2076307580 cites W2017764666 @default.
• W2076307580 cites W2019039336 @default.
• W2076307580 cites W2022852420 @default.
• W2076307580 cites W2027337589 @default.
• W2076307580 cites W2028156913 @default.
• W2076307580 cites W2031811219 @default.
• W2076307580 cites W2035555649 @default.
• W2076307580 cites W2038542171 @default.
• W2076307580 cites W2041709827 @default.
• W2076307580 cites W2057410806 @default.
• W2076307580 cites W2065299019 @default.
• W2076307580 cites W2080872140 @default.
• W2076307580 cites W2084994227 @default.
• W2076307580 cites W2091852263 @default.
• W2076307580 cites W2098237519 @default.
• W2076307580 cites W2100108036 @default.
• W2076307580 cites W2100146195 @default.
• W2076307580 cites W2110982852 @default.
• W2076307580 cites W2117677160 @default.
• W2076307580 cites W2139894498 @default.
• W2076307580 cites W2176899369 @default.
• W2076307580 doi "https://doi.org/10.1097/00002030-199704000-00004" @default.
• W2076307580 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9084788" @default.
• W2076307580 hasPublicationYear "1997" @default.
• W2076307580 type Work @default.
• W2076307580 sameAs 2076307580 @default.
• W2076307580 citedByCount "55" @default.
• W2076307580 countsByYear W20763075802012 @default.
• W2076307580 countsByYear W20763075802014 @default.
• W2076307580 crossrefType "journal-article" @default.
• W2076307580 hasAuthorship W2076307580A5006784170 @default.
• W2076307580 hasAuthorship W2076307580A5010330353 @default.
• W2076307580 hasAuthorship W2076307580A5016596102 @default.
• W2076307580 hasAuthorship W2076307580A5028653219 @default.
• W2076307580 hasAuthorship W2076307580A5039566477 @default.
• W2076307580 hasAuthorship W2076307580A5041365930 @default.
• W2076307580 hasAuthorship W2076307580A5072132268 @default.
• W2076307580 hasAuthorship W2076307580A5080467252 @default.
• W2076307580 hasBestOaLocation W20763075801 @default.
• W2076307580 hasConcept C104317684 @default.
• W2076307580 hasConcept C126322002 @default.
• W2076307580 hasConcept C156957248 @default.
• W2076307580 hasConcept C17991360 @default.
• W2076307580 hasConcept C180754005 @default.
• W2076307580 hasConcept C203014093 @default.
• W2076307580 hasConcept C54355233 @default.
• W2076307580 hasConcept C61320498 @default.
• W2076307580 hasConcept C71924100 @default.
• W2076307580 hasConcept C84597430 @default.
• W2076307580 hasConcept C86803240 @default.
• W2076307580 hasConceptScore W2076307580C104317684 @default.
• W2076307580 hasConceptScore W2076307580C126322002 @default.
• W2076307580 hasConceptScore W2076307580C156957248 @default.
• W2076307580 hasConceptScore W2076307580C17991360 @default.
• W2076307580 hasConceptScore W2076307580C180754005 @default.
• W2076307580 hasConceptScore W2076307580C203014093 @default.
• W2076307580 hasConceptScore W2076307580C54355233 @default.
• W2076307580 hasConceptScore W2076307580C61320498 @default.
• W2076307580 hasConceptScore W2076307580C71924100 @default.
• W2076307580 hasConceptScore W2076307580C84597430 @default.
• W2076307580 hasConceptScore W2076307580C86803240 @default.
• W2076307580 hasIssue "4" @default.
• W2076307580 hasLocation W20763075801 @default.
• W2076307580 hasLocation W20763075802 @default.
• W2076307580 hasLocation W20763075803 @default.
• W2076307580 hasOpenAccess W2076307580 @default.
• W2076307580 hasPrimaryLocation W20763075801 @default.
• W2076307580 hasRelatedWork W1968040222 @default.
• W2076307580 hasRelatedWork W1986695036 @default.
• W2076307580 hasRelatedWork W2003048454 @default.
• W2076307580 hasRelatedWork W2030972459 @default.
• W2076307580 hasRelatedWork W2111212937 @default.
• W2076307580 hasRelatedWork W2118062149 @default.
• W2076307580 hasRelatedWork W2152447148 @default.
• W2076307580 hasRelatedWork W2184383592 @default.
• W2076307580 hasRelatedWork W2360420393 @default.
• W2076307580 hasRelatedWork W2413099775 @default.
• W2076307580 hasVolume "11" @default.
• W2076307580 isParatext "false" @default.

• next