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• W2076312110 abstract "Repeated intraperitonal injection of nicotinamide (2 × 5 mmol/kg) in rats increases cardiac l-ornithine decarboxylase 36-fold in 4 h. This effect, which is dose dependent, is inhibited by cycloheximide. Cardiac l-ornithine decarboxylase decays with a t1/2 of 35 min. Nicotinic acid, at the same doses as nicotinamide, has only negligible effect on cardiac l-ornithine decarboxylase content. The calculated nicotinamide content of hearts is 11 mM, 30 min after the second injection of nicotinamide. Cardiac nicotinamide decays with a t1/2 of 3.1 h. Nicotinic acid increases cardiac nicotinamide content only to 1.1 mM. Injection of putrescine in doses which augment cardiac polyamine content to the same extent as nicotinamide-induced l-ornithine decarboxylase in vivo, inhibits the enzyme-inducing effect of nicotinamide within 30 min. The t1/2 of cardiac putrescine is 6.8 h. There is a temporal correlation between cardiac nicotinamide content, the cycle of induction of l-ornithine decarboxylase in 4 h, the subsequent decay of enzyme content and progressive inhibition of enzyme induction by putrescine. Induction of the protein inhibitor of l-ornithine decarboxylase, by repeated injections of putrescine, is a delayed second effect of the polyamine and has no kinetic relationship to the relatively rapid induction-decay cycle of l-ornithine decarboxylase elicited by nicotinamide. Within the experimental periods used, there is no effect of nicotinamide or putrescine on general protein synthesis in heart. Other inhibitors of poly(adenosine diphosphoribose) synthetase or nuclear NAD+ glycohydrolase (5′-methyl nicotinamide, thymidine or 3-isobutyl-1-methylxanthine) also induce l-ornithine decarboxylase. There is an apparent preferential inducing effect of nicotinamide on heart, whereas the other inhibitors act both on liver and heart to a varying extent." @default.
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• W2076312110 date "1978-11-01" @default.
• W2076312110 modified "2023-09-27" @default.
• W2076312110 title "Induction of Cardiac l-Ornithine Decarboxylase by Nicotinamide and Its Regulation by Putrescine" @default.
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• W2076312110 doi "https://doi.org/10.1111/j.1432-1033.1978.tb12711.x" @default.
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