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- W2076317967 abstract "Abstract 1. Isolated, superfused ventricles of Geukensia demissa demissa were soaked in artificial seawater containing radiocalcium (45Ca). The efflux of 45Ca into cold seawater was analyzed, and the effect of 5-hydroxytryptamine (5-HT) on the efflux was studied. 2. The control 45Ca efflux contained three identifiable components with the following time constants: τ1 = 2.27 ± 0.30 min; τ2 = 8.8 ± 1.1 min; and τ3 = 133.1 ± 39.2 min. 3. Excitation by 5-HT (10−6 M) caused an immediate systolic contracture and a transient increase in 45Ca efflux. The source of this efflux was depleted by a single, 10 min episode of 5-HT excitation. 4. When 5-HT was washed out, an efflux increase of long duration was observed. The time constant (9.3 ± 1.8 min) was identical to that of the second control component, τ2. 5. 5-HT caused excitation by decreasing the net calcium efflux, thereby increasing intracellular free calcium. No such change was associated with cardioinhibition by 5-HT." @default.
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- W2076317967 date "1981-01-01" @default.
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- W2076317967 title "Calcium fluxes accompanying the action of 5-hydroxytryptamine on mussel hearts" @default.
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- W2076317967 doi "https://doi.org/10.1016/0306-4492(81)90056-3" @default.
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