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• W2076319293 abstract "In Brief The mechanism of hypotension induced by anesthetics is not completely understood. Because no electrophysiologic examination of the effects of propofol on the central nervous system has shown its involvement in the control of sympathetic and cardiovascular functions, we investigated the actions of propofol on rat hypothalamic paraventricular nucleus (PVN) neurons using the whole-cell mode of the patch-clamp technique in rat hypothalamic PVN slice preparations. Propofol induced Cl− currents at concentrations of 10−5 and 10−4 M, which were sensitive to picrotoxin and, to a lesser extent, to strychnine. Propofol (10−6 M) enhanced γ-aminobutyric acidA (GABAA; 10−6 M)-induced current synergistically. Moreover, propofol (10−5 and 10−4 M) significantly increased the decay time of evoked-inhibitory postsynaptic currents, which suggests a postsynaptic modulation of GABAA receptors. In addition, propofol (10−5, 10−4, and 2 × 10−4 M) reversibly inhibited voltage-gated Ca2+ currents. Taken together, these results suggest that propofol enhancement of GABAA-receptor mediated currents and inhibition of voltage-gated Ca2+ currents at the central level, which is involved in the control of cardiovascular and sympathetic functions may be, at least in part, involved in general anesthetic-induced cardiovascular and sympathetic depression. IMPLICATIONS: We investigated the actions of propofol on the rat hypothalamic paraventricular nucleus neurons, which are involved in the control of cardiovascular and sympathetic functions. The results suggest that propofol enhancement of gamma-aminobutyric acidA-receptor mediated currents and inhibition of voltage-gated Ca2+ currents at the central level may be, at least in part, involved in general anesthetic-induced cardiovascular and sympathetic depression." @default.
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• W2076319293 date "2004-04-01" @default.
• W2076319293 modified "2023-10-18" @default.
• W2076319293 title "The Effects of Propofol on Hypothalamic Paraventricular Nucleus Neurons in the Rat" @default.
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• W2076319293 doi "https://doi.org/10.1213/01.ane.0000107960.89818.35" @default.
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