Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076320493> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2076320493 endingPage "36" @default.
- W2076320493 startingPage "33" @default.
- W2076320493 abstract "To investigate the possible role of cyclin-dependent kinase 5 (cdk5) in the formation of paired helical filaments (PHFs) in muscle of patients with inclusion-body myositis (IBM), we immunolocalized cdk5, by light- and electron- microscopy, in muscle biopsies of six IBM patients. Approximately 80-90% of IBM vacuolated muscle fibers, and 10-15% of nonvacuolated fibers, contained well defined cdk5-immunoreactive inclusions that colocalized with phosphorylated tau in 70-80% of those fibers. Immunoelectronmicroscopy revealed the association of cdk5 with tau-immunoreactive PHFs. In all biopsies that contained them, regenerating muscle fibers had diffuse, moderate to strong cdk5 immunoreactivity. At all neuromuscular junctions, there was strong cdk5 immunoreactivity postsynaptically. Our study suggests that cdk5: (1) plays a role in IBM pathogenesis, possibly mediating phosphorylation of PHF-related tau; (2) is involved in muscle regeneration; and (3) has a novel function at normal neuromuscular junctions." @default.
- W2076320493 created "2016-06-24" @default.
- W2076320493 creator A5008326837 @default.
- W2076320493 creator A5029701142 @default.
- W2076320493 creator A5070005083 @default.
- W2076320493 date "2000-10-01" @default.
- W2076320493 modified "2023-09-28" @default.
- W2076320493 title "Cyclin-dependent kinase 5 colocalizes with phosphorylated tau in human inclusion-body myositis paired-helical filaments and may play a role in tau phosphorylation" @default.
- W2076320493 cites W1563116834 @default.
- W2076320493 cites W1577397450 @default.
- W2076320493 cites W1967513322 @default.
- W2076320493 cites W1969706399 @default.
- W2076320493 cites W1970460796 @default.
- W2076320493 cites W1979268652 @default.
- W2076320493 cites W1983904065 @default.
- W2076320493 cites W1984482388 @default.
- W2076320493 cites W1999158509 @default.
- W2076320493 cites W2006152491 @default.
- W2076320493 cites W2008308614 @default.
- W2076320493 cites W2021696285 @default.
- W2076320493 cites W2031179697 @default.
- W2076320493 cites W2048560678 @default.
- W2076320493 cites W2062772621 @default.
- W2076320493 cites W2072753625 @default.
- W2076320493 cites W2119981808 @default.
- W2076320493 cites W2134133501 @default.
- W2076320493 doi "https://doi.org/10.1016/s0304-3940(00)01485-3" @default.
- W2076320493 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11065131" @default.
- W2076320493 hasPublicationYear "2000" @default.
- W2076320493 type Work @default.
- W2076320493 sameAs 2076320493 @default.
- W2076320493 citedByCount "19" @default.
- W2076320493 countsByYear W20763204932012 @default.
- W2076320493 countsByYear W20763204932013 @default.
- W2076320493 countsByYear W20763204932021 @default.
- W2076320493 countsByYear W20763204932022 @default.
- W2076320493 crossrefType "journal-article" @default.
- W2076320493 hasAuthorship W2076320493A5008326837 @default.
- W2076320493 hasAuthorship W2076320493A5029701142 @default.
- W2076320493 hasAuthorship W2076320493A5070005083 @default.
- W2076320493 hasConcept C105702510 @default.
- W2076320493 hasConcept C11960822 @default.
- W2076320493 hasConcept C121738310 @default.
- W2076320493 hasConcept C142669718 @default.
- W2076320493 hasConcept C142724271 @default.
- W2076320493 hasConcept C1491633281 @default.
- W2076320493 hasConcept C184235292 @default.
- W2076320493 hasConcept C185592680 @default.
- W2076320493 hasConcept C2777327098 @default.
- W2076320493 hasConcept C2781232998 @default.
- W2076320493 hasConcept C55493867 @default.
- W2076320493 hasConcept C71924100 @default.
- W2076320493 hasConcept C78383274 @default.
- W2076320493 hasConcept C82495950 @default.
- W2076320493 hasConcept C86803240 @default.
- W2076320493 hasConcept C95444343 @default.
- W2076320493 hasConcept C97029542 @default.
- W2076320493 hasConceptScore W2076320493C105702510 @default.
- W2076320493 hasConceptScore W2076320493C11960822 @default.
- W2076320493 hasConceptScore W2076320493C121738310 @default.
- W2076320493 hasConceptScore W2076320493C142669718 @default.
- W2076320493 hasConceptScore W2076320493C142724271 @default.
- W2076320493 hasConceptScore W2076320493C1491633281 @default.
- W2076320493 hasConceptScore W2076320493C184235292 @default.
- W2076320493 hasConceptScore W2076320493C185592680 @default.
- W2076320493 hasConceptScore W2076320493C2777327098 @default.
- W2076320493 hasConceptScore W2076320493C2781232998 @default.
- W2076320493 hasConceptScore W2076320493C55493867 @default.
- W2076320493 hasConceptScore W2076320493C71924100 @default.
- W2076320493 hasConceptScore W2076320493C78383274 @default.
- W2076320493 hasConceptScore W2076320493C82495950 @default.
- W2076320493 hasConceptScore W2076320493C86803240 @default.
- W2076320493 hasConceptScore W2076320493C95444343 @default.
- W2076320493 hasConceptScore W2076320493C97029542 @default.
- W2076320493 hasIssue "1" @default.
- W2076320493 hasLocation W20763204931 @default.
- W2076320493 hasLocation W20763204932 @default.
- W2076320493 hasOpenAccess W2076320493 @default.
- W2076320493 hasPrimaryLocation W20763204931 @default.
- W2076320493 hasRelatedWork W1977381318 @default.
- W2076320493 hasRelatedWork W1984880380 @default.
- W2076320493 hasRelatedWork W2026886450 @default.
- W2076320493 hasRelatedWork W2035067386 @default.
- W2076320493 hasRelatedWork W2052704830 @default.
- W2076320493 hasRelatedWork W2076320493 @default.
- W2076320493 hasRelatedWork W2413360166 @default.
- W2076320493 hasRelatedWork W2526232652 @default.
- W2076320493 hasRelatedWork W4297900568 @default.
- W2076320493 hasRelatedWork W66135227 @default.
- W2076320493 hasVolume "293" @default.
- W2076320493 isParatext "false" @default.
- W2076320493 isRetracted "false" @default.
- W2076320493 magId "2076320493" @default.
- W2076320493 workType "article" @default.