Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076320590> ?p ?o ?g. }
- W2076320590 endingPage "805" @default.
- W2076320590 startingPage "799" @default.
- W2076320590 abstract "Precise and quantitative control of extracellular signalling cues using surface-engineered chips has facilitated various neurobiological assays in vitro. Although the formation of axon collateral branches is important for the establishment and refinement of the neuronal connections during the development and regeneration, surface designs for controlling branch phenotypes have been rarely proposed. In this work, we fabricated a surface-printed microdot array for controlling axon branch formation. Following the culture of hippocampal neurons on a 5 μm dot array patterned by micro-contact printing of poly-d-lysine, we found that most axon collateral branches were initiated from axonal regions on a microdot and terminated on neighboring dots. In addition, the length of branches increased as the spacing between dots increased. Surprisingly, other morphological features were not significantly different from the neurons cultured on a conventional unpatterned surface. Further investigation of this phenomenon indicated that the branch-forming machineries, such as actin patches, were focused on the dot. According to these investigations, we concluded that discontinuous adhesion spots given by dot arrays arranged the branching formation on the expectable location and direction. Therefore, microdot arrays will be applicable as the surface design parameter of bio-chip platforms to reduce branching complexity and quantize branching formation for the simple and easy assay in neurobiological studies." @default.
- W2076320590 created "2016-06-24" @default.
- W2076320590 creator A5013585270 @default.
- W2076320590 creator A5029757025 @default.
- W2076320590 creator A5061203886 @default.
- W2076320590 creator A5062040384 @default.
- W2076320590 creator A5067648984 @default.
- W2076320590 date "2014-01-01" @default.
- W2076320590 modified "2023-09-24" @default.
- W2076320590 title "Surface-printed microdot array chips for the quantification of axonal collateral branching of a single neuron in vitro" @default.
- W2076320590 cites W110398411 @default.
- W2076320590 cites W160351337 @default.
- W2076320590 cites W1895213472 @default.
- W2076320590 cites W1928244427 @default.
- W2076320590 cites W1967060076 @default.
- W2076320590 cites W1970693961 @default.
- W2076320590 cites W1981817841 @default.
- W2076320590 cites W1987739439 @default.
- W2076320590 cites W1998596632 @default.
- W2076320590 cites W2002270164 @default.
- W2076320590 cites W2002545202 @default.
- W2076320590 cites W2018723867 @default.
- W2076320590 cites W2019468320 @default.
- W2076320590 cites W2021701663 @default.
- W2076320590 cites W2025129596 @default.
- W2076320590 cites W2051720591 @default.
- W2076320590 cites W2053552455 @default.
- W2076320590 cites W2062875886 @default.
- W2076320590 cites W2064591722 @default.
- W2076320590 cites W2090417896 @default.
- W2076320590 cites W2094177900 @default.
- W2076320590 cites W2112866667 @default.
- W2076320590 cites W2126552458 @default.
- W2076320590 cites W2129393031 @default.
- W2076320590 cites W2135688478 @default.
- W2076320590 cites W2137802487 @default.
- W2076320590 cites W2147254436 @default.
- W2076320590 cites W2154465669 @default.
- W2076320590 cites W2155983695 @default.
- W2076320590 cites W2163288138 @default.
- W2076320590 cites W2163520351 @default.
- W2076320590 doi "https://doi.org/10.1039/c3lc51169c" @default.
- W2076320590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24366209" @default.
- W2076320590 hasPublicationYear "2014" @default.
- W2076320590 type Work @default.
- W2076320590 sameAs 2076320590 @default.
- W2076320590 citedByCount "26" @default.
- W2076320590 countsByYear W20763205902015 @default.
- W2076320590 countsByYear W20763205902016 @default.
- W2076320590 countsByYear W20763205902017 @default.
- W2076320590 countsByYear W20763205902018 @default.
- W2076320590 countsByYear W20763205902019 @default.
- W2076320590 countsByYear W20763205902021 @default.
- W2076320590 countsByYear W20763205902022 @default.
- W2076320590 countsByYear W20763205902023 @default.
- W2076320590 crossrefType "journal-article" @default.
- W2076320590 hasAuthorship W2076320590A5013585270 @default.
- W2076320590 hasAuthorship W2076320590A5029757025 @default.
- W2076320590 hasAuthorship W2076320590A5061203886 @default.
- W2076320590 hasAuthorship W2076320590A5062040384 @default.
- W2076320590 hasAuthorship W2076320590A5067648984 @default.
- W2076320590 hasConcept C113246987 @default.
- W2076320590 hasConcept C12554922 @default.
- W2076320590 hasConcept C136229726 @default.
- W2076320590 hasConcept C159985019 @default.
- W2076320590 hasConcept C169760540 @default.
- W2076320590 hasConcept C171250308 @default.
- W2076320590 hasConcept C192562407 @default.
- W2076320590 hasConcept C202751555 @default.
- W2076320590 hasConcept C206175624 @default.
- W2076320590 hasConcept C2779530196 @default.
- W2076320590 hasConcept C3019308078 @default.
- W2076320590 hasConcept C55493867 @default.
- W2076320590 hasConcept C71924100 @default.
- W2076320590 hasConcept C86803240 @default.
- W2076320590 hasConceptScore W2076320590C113246987 @default.
- W2076320590 hasConceptScore W2076320590C12554922 @default.
- W2076320590 hasConceptScore W2076320590C136229726 @default.
- W2076320590 hasConceptScore W2076320590C159985019 @default.
- W2076320590 hasConceptScore W2076320590C169760540 @default.
- W2076320590 hasConceptScore W2076320590C171250308 @default.
- W2076320590 hasConceptScore W2076320590C192562407 @default.
- W2076320590 hasConceptScore W2076320590C202751555 @default.
- W2076320590 hasConceptScore W2076320590C206175624 @default.
- W2076320590 hasConceptScore W2076320590C2779530196 @default.
- W2076320590 hasConceptScore W2076320590C3019308078 @default.
- W2076320590 hasConceptScore W2076320590C55493867 @default.
- W2076320590 hasConceptScore W2076320590C71924100 @default.
- W2076320590 hasConceptScore W2076320590C86803240 @default.
- W2076320590 hasIssue "4" @default.
- W2076320590 hasLocation W20763205901 @default.
- W2076320590 hasLocation W20763205902 @default.
- W2076320590 hasOpenAccess W2076320590 @default.
- W2076320590 hasPrimaryLocation W20763205901 @default.
- W2076320590 hasRelatedWork W1926203410 @default.
- W2076320590 hasRelatedWork W1967424438 @default.
- W2076320590 hasRelatedWork W1967491977 @default.
- W2076320590 hasRelatedWork W2000272148 @default.