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- W2076320830 abstract "Two structural classes of dual alpha4beta1/alpha4beta7 integrin antagonists were investigated via solid-phase parallel synthesis. Using an acylated amino acid backbone, lead compounds containing biphenylalanine or tyrosine carbamate scaffolds were optimized for inhibition of alpha4beta1/VCAM and alpha4beta7/MAdCAM. A comparison of the structure-activity relationships in the inhibition of the alpha4beta7/MAdCAM interaction for substituted amines employed in both scaffolds suggests a similar binding mode for the compounds." @default.
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- W2076320830 date "2002-10-01" @default.
- W2076320830 modified "2023-09-27" @default.
- W2076320830 title "Solid-phase synthesis of dual α4β1/α4β7 integrin antagonists: two scaffolds with overlapping pharmacophores" @default.
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- W2076320830 doi "https://doi.org/10.1016/s0960-894x(02)00597-8" @default.
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