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• W2076320871 abstract "We conducted a critical assessment of the use of diets high in fat and low in carbohydrate (ketogenic) in the treatment of children with congenital lactic acidosis caused by mutations in the mitochondrial pyruvate dehydrogenase complex (PDC).The dietary composition of 18 subjects (11 from literature sources and 7 previously unpublished cases) was analyzed for nutrient composition. The biochemical and clinical responses to a long-term ketogenic regimen were also evaluated.There was lack of uniformity in the proportion of fat calories administered and in the fatty acid composition of the diets. Ketogenic diets are also generally high in protein, compared with the recommended dietary allowance for age. Patient response to these regimens also varied considerably.Although ketogenic diets have become the standard of care for the treatment of PDC deficiency, data to support their use are based on a few uncontrolled case reports in which dietary composition varied widely. Furthermore, there are several theoretical reasons for concern about the long-term safety of high-fat, low-carbohydrate diets. A controlled, prospective evaluation of the risks and benefits of these regimens for patients with PDC deficiency is required to establish rational nutritional guidelines." @default.
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• W2076320871 date "2001-03-01" @default.
• W2076320871 modified "2023-10-06" @default.
• W2076320871 title "Caveats when considering ketogenic diets for the treatment of pyruvate dehydrogenase complex deficiency" @default.
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• W2076320871 doi "https://doi.org/10.1067/mpd.2001.111817" @default.
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