FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076321618> ?p ?o ?g. }

• W2076321618 endingPage "395" @default.
• W2076321618 startingPage "386" @default.
• W2076321618 abstract "Background: Helicobacter pylori (Hp) infection is involved in various gastroduodenal pathologies. Also, the potential role of Hp infection has been proposed in several extragastroduodenal disorders, such as cardiovascular, skin or immunological diseases. The role of Hp infection in acute pancreatitis has not been tested. The aim of this study was to determine the influence of Hp infection on the course of acute ischemia/reperfusioninduced pancreatitis in rats. Methods: Inoculation with CagAand VacA-positive Hp or administration of vehicle were performed after visceral ischemia. Visceral ischemia was evoked by clamping of the celiac artery for 30 min. Four weeks later, after full recovery from primary ischemia-induced damage, acute pancreatitis was evoked by limitation of pancreatic blood flow (PBF) in the splenic artery for 30 min using microvascular clips. Rats were sacrificed 1 h or 1, 3, 5, 10, and 21 days after removal of the vascular clips. Hp infection was assessed by the urease test and gastric histology. Results: In Hp-negative rats ischemia followed by reperfusion caused acute pancreatitis as manifested by a reduction in PBF and pancreatic DNA synthesis, as well as by increases in plasma amylase, lipase, interleukin-1ß (IL-1ß) and interleukin-10 (IL-10). The morphological features of pancreatic tissue showed necrosis, strongly pronounced edema, hemorrhages and leukocyte infiltration. The maximal intensity of pancreatic damage was observed between the 1st and 3rd day of reperfusion, then pancreatic tissue underwent regeneration. Hp infection resulted in a significant reduction in PBF and an aggravation of pancreatic ischemia 1 h and 3 and 5 days after reperfusion. Plasma amylase in Hp-infected rats was significantly higher than in Hpnegative animals 1 h and 1 and 3 days after ischemia, whereas in lipase this significant difference was observed between the 1st and 3rd day. DNA synthesis in Hp-positive rats was additionally reduced 1 h and 3 and 5 days after ischemia. Also ischemia evoked an increase in serum IL-1ß and IL-10, and morphological manifestations of pancreatitis were additionally enhanced by Hp infection. Conclusions: (1) Hp infection increases the severity of ischemia-induced pancreatitis; (2) Hp infection increases production of pro-inflammatory IL-1ß, and (3) Hp infection aggravates disturbances in pancreatic microcirculation in acute pancreatitis." @default.
• W2076321618 created "2016-06-24" @default.
• W2076321618 creator A5027168651 @default.
• W2076321618 creator A5037927286 @default.
• W2076321618 creator A5052407385 @default.
• W2076321618 creator A5061074084 @default.
• W2076321618 creator A5089627000 @default.
• W2076321618 creator A5090819846 @default.
• W2076321618 date "2002-01-01" @default.
• W2076321618 modified "2023-10-03" @default.
• W2076321618 title "Deleterious Effect of Helicobacter pylori Infection on the Course of Acute Pancreatitis in Rats" @default.
• W2076321618 cites W1258042975 @default.
• W2076321618 cites W135253366 @default.
• W2076321618 cites W1479924539 @default.
• W2076321618 cites W1500578507 @default.
• W2076321618 cites W1534982687 @default.
• W2076321618 cites W1560794427 @default.
• W2076321618 cites W1574330564 @default.
• W2076321618 cites W1922458276 @default.
• W2076321618 cites W1933287277 @default.
• W2076321618 cites W1965455018 @default.
• W2076321618 cites W1969764255 @default.
• W2076321618 cites W1979273869 @default.
• W2076321618 cites W1983713239 @default.
• W2076321618 cites W1989107717 @default.
• W2076321618 cites W1989620947 @default.
• W2076321618 cites W2007068357 @default.
• W2076321618 cites W2013751835 @default.
• W2076321618 cites W2023060921 @default.
• W2076321618 cites W2023311785 @default.
• W2076321618 cites W2031599350 @default.
• W2076321618 cites W2034338667 @default.
• W2076321618 cites W2035155532 @default.
• W2076321618 cites W2042024393 @default.
• W2076321618 cites W2044748329 @default.
• W2076321618 cites W2045401570 @default.
• W2076321618 cites W2049251247 @default.
• W2076321618 cites W2050328899 @default.
• W2076321618 cites W2061269008 @default.
• W2076321618 cites W2064149227 @default.
• W2076321618 cites W2072304449 @default.
• W2076321618 cites W2075642347 @default.
• W2076321618 cites W2080825159 @default.
• W2076321618 cites W2092727047 @default.
• W2076321618 cites W2101112318 @default.
• W2076321618 cites W2140000072 @default.
• W2076321618 cites W2191654227 @default.
• W2076321618 cites W2321415533 @default.
• W2076321618 cites W337659562 @default.
• W2076321618 cites W4231581694 @default.
• W2076321618 cites W4322703275 @default.
• W2076321618 cites W4367283593 @default.
• W2076321618 doi "https://doi.org/10.1159/000065086" @default.
• W2076321618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12138227" @default.
• W2076321618 hasPublicationYear "2002" @default.
• W2076321618 type Work @default.
• W2076321618 sameAs 2076321618 @default.
• W2076321618 citedByCount "31" @default.
• W2076321618 countsByYear W20763216182014 @default.
• W2076321618 countsByYear W20763216182015 @default.
• W2076321618 countsByYear W20763216182016 @default.
• W2076321618 countsByYear W20763216182017 @default.
• W2076321618 countsByYear W20763216182018 @default.
• W2076321618 countsByYear W20763216182019 @default.
• W2076321618 countsByYear W20763216182020 @default.
• W2076321618 countsByYear W20763216182021 @default.
• W2076321618 countsByYear W20763216182022 @default.
• W2076321618 countsByYear W20763216182023 @default.
• W2076321618 crossrefType "journal-article" @default.
• W2076321618 hasAuthorship W2076321618A5027168651 @default.
• W2076321618 hasAuthorship W2076321618A5037927286 @default.
• W2076321618 hasAuthorship W2076321618A5052407385 @default.
• W2076321618 hasAuthorship W2076321618A5061074084 @default.
• W2076321618 hasAuthorship W2076321618A5089627000 @default.
• W2076321618 hasAuthorship W2076321618A5090819846 @default.
• W2076321618 hasBestOaLocation W20763216181 @default.
• W2076321618 hasConcept C126322002 @default.
• W2076321618 hasConcept C141071460 @default.
• W2076321618 hasConcept C142724271 @default.
• W2076321618 hasConcept C2775967933 @default.
• W2076321618 hasConcept C2776670229 @default.
• W2076321618 hasConcept C2780333324 @default.
• W2076321618 hasConcept C2780886150 @default.
• W2076321618 hasConcept C541997718 @default.
• W2076321618 hasConcept C71924100 @default.
• W2076321618 hasConcept C90924648 @default.
• W2076321618 hasConceptScore W2076321618C126322002 @default.
• W2076321618 hasConceptScore W2076321618C141071460 @default.
• W2076321618 hasConceptScore W2076321618C142724271 @default.
• W2076321618 hasConceptScore W2076321618C2775967933 @default.
• W2076321618 hasConceptScore W2076321618C2776670229 @default.
• W2076321618 hasConceptScore W2076321618C2780333324 @default.
• W2076321618 hasConceptScore W2076321618C2780886150 @default.
• W2076321618 hasConceptScore W2076321618C541997718 @default.
• W2076321618 hasConceptScore W2076321618C71924100 @default.
• W2076321618 hasConceptScore W2076321618C90924648 @default.
• W2076321618 hasIssue "4" @default.
• W2076321618 hasLocation W20763216181 @default.

• next