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• W2076324043 abstract "In many instances, remote signaling involves the transport of secreted molecules. Here, we examine the spread of Wingless within the embryonic epidermis of Drosophila. Using two assays for Wingless activity (specification of naked cuticle and repression of rhomboid transcription), we found that Wingless acts at a different range in the anterior and posterior directions. We show that this asymmetry follows in part from differential distribution of the Wingless protein. Transport or stability is reduced within engrailed-expressing cells, and farther posteriorward Wingless movement is blocked at the presumptive segment boundary and perhaps beyond. We demonstrate the role of hedgehog in the formation of this barrier." @default.
• W2076324043 created "2016-06-24" @default.
• W2076324043 creator A5037269824 @default.
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• W2076324043 date "1999-07-01" @default.
• W2076324043 modified "2023-09-23" @default.
• W2076324043 title "Engrailed and Hedgehog Make the Range of Wingless Asymmetric in Drosophila Embryos" @default.
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• W2076324043 doi "https://doi.org/10.1016/s0092-8674(00)81015-6" @default.
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