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• W2076324340 abstract "The use of paclitaxel (Taxol), a microtubule stabilizer, for cancer treatment is often limited by its associated peripheral neuropathy (chemotherapy-induced peripheral neuropathy [CIPN]), which predominantly results in sensory dysfunction, including chronic pain. Here we show that paclitaxel CIPN was associated with induction of chemokine monocyte chemoattractant protein-1 (MCP-1) and its cognate receptor CCR2 in primary sensory neurons of dorsal root ganglia. Immunostaining revealed that MCP-1 was mainly expressed in small nociceptive neurons whereas CCR2 was expressed in large and medium-sized myelinated neurons. Direct application of MCP-1 consistently induced intracellular calcium increases in dorsal root ganglia large and medium-sized neurons but not in small neurons mainly dissociated from paclitaxel-treated but not vehicle-treated animals. Paclitaxel also induced increased expression of MCP-1 in spinal astrocytes, but no CCR2 signal was detected in the spinal cord. Local blockade of MCP-1/CCR2 signaling by anti-MCP-1 antibody or CCR2 antisense oligodeoxynucleotides significantly attenuated paclitaxel CIPN phenotypes including mechanical hypersensitivity and loss of intraepidermal nerve fibers in hindpaw glabrous skin. These results suggest that activation of paracrine MCP-1/CCR2 signaling between dorsal root ganglion neurons plays a critical role in the development of paclitaxel CIPN, and targeting MCP-1/CCR2 signaling could be a novel therapeutic approach. Perspective CIPN is a severe side effect accompanying paclitaxel chemotherapy and lacks effective treatments. The current study suggests that blocking MCP-1/CCR2 signaling could be a new therapeutic strategy to prevent or reverse paclitaxel CIPN. This preclinical evidence encourages future clinical evaluation of this strategy." @default.
• W2076324340 created "2016-06-24" @default.
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• W2076324340 date "2013-10-01" @default.
• W2076324340 modified "2023-10-14" @default.
• W2076324340 title "Induction of Monocyte Chemoattractant Protein-1 (MCP-1) and Its Receptor CCR2 in Primary Sensory Neurons Contributes to Paclitaxel-Induced Peripheral Neuropathy" @default.
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• W2076324340 cites W1952350508 @default.
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• W2076324340 cites W1972286844 @default.
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• W2076324340 cites W2000814289 @default.
• W2076324340 cites W2002692790 @default.
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• W2076324340 cites W2022898812 @default.
• W2076324340 cites W2023592074 @default.
• W2076324340 cites W2026861786 @default.
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• W2076324340 cites W2053034826 @default.
• W2076324340 cites W2055397053 @default.
• W2076324340 cites W2059588106 @default.
• W2076324340 cites W2062071281 @default.
• W2076324340 cites W2067711649 @default.
• W2076324340 cites W2068259110 @default.
• W2076324340 cites W2069302399 @default.
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• W2076324340 cites W2106012138 @default.
• W2076324340 cites W2113651400 @default.
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• W2076324340 doi "https://doi.org/10.1016/j.jpain.2013.03.012" @default.
• W2076324340 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3791166" @default.
• W2076324340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23726937" @default.
• W2076324340 hasPublicationYear "2013" @default.
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