Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076327263> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2076327263 endingPage "404" @default.
- W2076327263 startingPage "399" @default.
- W2076327263 abstract "OPC-18790 is a positive inotropic and vasodilating agent that increases intracellular cyclic AMP and stimulates Ca currents. We examined its direct electrophysiological effects in isolated blood-perfused canine cardiac preparations. OPC-18790 caused an acceleration of the intraventricular conduction in association with an increase of the contractile force and the coronary blood flow. We also examined the effects of OPC-18790 on ventricular arrhythmias in canine ventricular tachycardia (VT) models. OPC-18790 in doses producing submaximal inotropic effects, 3 mg/kg, i.v., increased the total heart rate, atrial rate and decreased the blood pressure, but did not suppress or aggravate 24- and 48-hr coronary ligation VTs. OPC-18790 up to 3 mg/kg, i.v. also did not suppress or aggravate digitalis-induced VTs. However, this dose of OPC-18790 aggravated halothane-adrenaline induced VT into ventricular fibrillation and eventually death, but a lower dose of 0.3 mg/kg did not aggravate this VT. These results in canine VTs indicate that OPC-18790 is similar to other positive inotropic agents, vesnarinone, amrinone, milrinone and sulmazole. The absence of an aggravating effect of this new positive inotropic agent on digitalis and coronary ligation VTs may be advantageous in a clinical setting of combined therapy with digitalis for myocardial ischemia." @default.
- W2076327263 created "2016-06-24" @default.
- W2076327263 creator A5003482863 @default.
- W2076327263 creator A5010970070 @default.
- W2076327263 creator A5028565031 @default.
- W2076327263 creator A5040452518 @default.
- W2076327263 creator A5080214360 @default.
- W2076327263 date "1993-01-01" @default.
- W2076327263 modified "2023-10-14" @default.
- W2076327263 title "Effects of OPC-18790, a New Positive Inotropic Agent, on Canine Ventricular Arrhythmias" @default.
- W2076327263 cites W1985084727 @default.
- W2076327263 cites W2009630293 @default.
- W2076327263 cites W2014126765 @default.
- W2076327263 cites W2024384450 @default.
- W2076327263 cites W2037117401 @default.
- W2076327263 cites W2038513066 @default.
- W2076327263 cites W2085909441 @default.
- W2076327263 cites W2095019719 @default.
- W2076327263 cites W2153223961 @default.
- W2076327263 cites W2270744019 @default.
- W2076327263 cites W2417750340 @default.
- W2076327263 cites W2419573995 @default.
- W2076327263 cites W89016540 @default.
- W2076327263 doi "https://doi.org/10.1254/jjp.63.399" @default.
- W2076327263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8107332" @default.
- W2076327263 hasPublicationYear "1993" @default.
- W2076327263 type Work @default.
- W2076327263 sameAs 2076327263 @default.
- W2076327263 citedByCount "14" @default.
- W2076327263 crossrefType "journal-article" @default.
- W2076327263 hasAuthorship W2076327263A5003482863 @default.
- W2076327263 hasAuthorship W2076327263A5010970070 @default.
- W2076327263 hasAuthorship W2076327263A5028565031 @default.
- W2076327263 hasAuthorship W2076327263A5040452518 @default.
- W2076327263 hasAuthorship W2076327263A5080214360 @default.
- W2076327263 hasBestOaLocation W20763272631 @default.
- W2076327263 hasConcept C126322002 @default.
- W2076327263 hasConcept C155710745 @default.
- W2076327263 hasConcept C158328960 @default.
- W2076327263 hasConcept C164705383 @default.
- W2076327263 hasConcept C2776331378 @default.
- W2076327263 hasConcept C2776445394 @default.
- W2076327263 hasConcept C2777953023 @default.
- W2076327263 hasConcept C2778198053 @default.
- W2076327263 hasConcept C2779739782 @default.
- W2076327263 hasConcept C2781005686 @default.
- W2076327263 hasConcept C42219234 @default.
- W2076327263 hasConcept C71924100 @default.
- W2076327263 hasConcept C84393581 @default.
- W2076327263 hasConceptScore W2076327263C126322002 @default.
- W2076327263 hasConceptScore W2076327263C155710745 @default.
- W2076327263 hasConceptScore W2076327263C158328960 @default.
- W2076327263 hasConceptScore W2076327263C164705383 @default.
- W2076327263 hasConceptScore W2076327263C2776331378 @default.
- W2076327263 hasConceptScore W2076327263C2776445394 @default.
- W2076327263 hasConceptScore W2076327263C2777953023 @default.
- W2076327263 hasConceptScore W2076327263C2778198053 @default.
- W2076327263 hasConceptScore W2076327263C2779739782 @default.
- W2076327263 hasConceptScore W2076327263C2781005686 @default.
- W2076327263 hasConceptScore W2076327263C42219234 @default.
- W2076327263 hasConceptScore W2076327263C71924100 @default.
- W2076327263 hasConceptScore W2076327263C84393581 @default.
- W2076327263 hasIssue "3" @default.
- W2076327263 hasLocation W20763272631 @default.
- W2076327263 hasLocation W20763272632 @default.
- W2076327263 hasOpenAccess W2076327263 @default.
- W2076327263 hasPrimaryLocation W20763272631 @default.
- W2076327263 hasRelatedWork W1968379034 @default.
- W2076327263 hasRelatedWork W1985084727 @default.
- W2076327263 hasRelatedWork W2034380089 @default.
- W2076327263 hasRelatedWork W2075632801 @default.
- W2076327263 hasRelatedWork W2076327263 @default.
- W2076327263 hasRelatedWork W2148744270 @default.
- W2076327263 hasRelatedWork W2166495696 @default.
- W2076327263 hasRelatedWork W2265298187 @default.
- W2076327263 hasRelatedWork W2990292045 @default.
- W2076327263 hasRelatedWork W2739536534 @default.
- W2076327263 hasVolume "63" @default.
- W2076327263 isParatext "false" @default.
- W2076327263 isRetracted "false" @default.
- W2076327263 magId "2076327263" @default.
- W2076327263 workType "article" @default.