FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076329702> ?p ?o ?g. }

• W2076329702 endingPage "e1002439" @default.
• W2076329702 startingPage "e1002439" @default.
• W2076329702 abstract "Common genetic variants have been shown to explain a fraction of the inherited variation for many common diseases and quantitative traits, including height, a classic polygenic trait. The extent to which common variation determines the phenotype of highly heritable traits such as height is uncertain, as is the extent to which common variation is relevant to individuals with more extreme phenotypes. To address these questions, we studied 1,214 individuals from the top and bottom extremes of the height distribution (tallest and shortest ∼1.5%), drawn from ∼78,000 individuals from the HUNT and FINRISK cohorts. We found that common variants still influence height at the extremes of the distribution: common variants (49/141) were nominally associated with height in the expected direction more often than is expected by chance (p<5×10−28), and the odds ratios in the extreme samples were consistent with the effects estimated previously in population-based data. To examine more closely whether the common variants have the expected effects, we calculated a weighted allele score (WAS), which is a weighted prediction of height for each individual based on the previously estimated effect sizes of the common variants in the overall population. The average WAS is consistent with expectation in the tall individuals, but was not as extreme as expected in the shortest individuals (p<0.006), indicating that some of the short stature is explained by factors other than common genetic variation. The discrepancy was more pronounced (p<10−6) in the most extreme individuals (height<0.25 percentile). The results at the extreme short tails are consistent with a large number of models incorporating either rare genetic non-additive or rare non-genetic factors that decrease height. We conclude that common genetic variants are associated with height at the extremes as well as across the population, but that additional factors become more prominent at the shorter extreme." @default.
• W2076329702 created "2016-06-24" @default.
• W2076329702 creator A5001552586 @default.
• W2076329702 creator A5003810507 @default.
• W2076329702 creator A5012256625 @default.
• W2076329702 creator A5013403466 @default.
• W2076329702 creator A5014862057 @default.
• W2076329702 creator A5030267686 @default.
• W2076329702 creator A5033780024 @default.
• W2076329702 creator A5037540437 @default.
• W2076329702 creator A5039731517 @default.
• W2076329702 creator A5045621057 @default.
• W2076329702 creator A5047212574 @default.
• W2076329702 creator A5051610805 @default.
• W2076329702 creator A5052307736 @default.
• W2076329702 creator A5054656133 @default.
• W2076329702 creator A5056663920 @default.
• W2076329702 creator A5066237154 @default.
• W2076329702 creator A5070817744 @default.
• W2076329702 creator A5085708490 @default.
• W2076329702 date "2011-12-29" @default.
• W2076329702 modified "2023-10-16" @default.
• W2076329702 title "Common Variants Show Predicted Polygenic Effects on Height in the Tails of the Distribution, Except in Extremely Short Individuals" @default.
• W2076329702 cites W1531142817 @default.
• W2076329702 cites W1979164118 @default.
• W2076329702 cites W1980991473 @default.
• W2076329702 cites W2010038148 @default.
• W2076329702 cites W2038353297 @default.
• W2076329702 cites W2051008597 @default.
• W2076329702 cites W2064221624 @default.
• W2076329702 cites W2091583677 @default.
• W2076329702 cites W2098126593 @default.
• W2076329702 cites W2099047497 @default.
• W2076329702 cites W2109333627 @default.
• W2076329702 cites W2128335879 @default.
• W2076329702 cites W2128476271 @default.
• W2076329702 cites W2150856909 @default.
• W2076329702 cites W2157752701 @default.
• W2076329702 cites W2157920911 @default.
• W2076329702 cites W2161633633 @default.
• W2076329702 cites W2163285329 @default.
• W2076329702 cites W2167638767 @default.
• W2076329702 doi "https://doi.org/10.1371/journal.pgen.1002439" @default.
• W2076329702 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3248463" @default.
• W2076329702 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22242009" @default.
• W2076329702 hasPublicationYear "2011" @default.
• W2076329702 type Work @default.
• W2076329702 sameAs 2076329702 @default.
• W2076329702 citedByCount "50" @default.
• W2076329702 countsByYear W20763297022012 @default.
• W2076329702 countsByYear W20763297022013 @default.
• W2076329702 countsByYear W20763297022014 @default.
• W2076329702 countsByYear W20763297022015 @default.
• W2076329702 countsByYear W20763297022016 @default.
• W2076329702 countsByYear W20763297022017 @default.
• W2076329702 countsByYear W20763297022018 @default.
• W2076329702 countsByYear W20763297022019 @default.
• W2076329702 countsByYear W20763297022020 @default.
• W2076329702 countsByYear W20763297022021 @default.
• W2076329702 countsByYear W20763297022022 @default.
• W2076329702 countsByYear W20763297022023 @default.
• W2076329702 crossrefType "journal-article" @default.
• W2076329702 hasAuthorship W2076329702A5001552586 @default.
• W2076329702 hasAuthorship W2076329702A5003810507 @default.
• W2076329702 hasAuthorship W2076329702A5012256625 @default.
• W2076329702 hasAuthorship W2076329702A5013403466 @default.
• W2076329702 hasAuthorship W2076329702A5014862057 @default.
• W2076329702 hasAuthorship W2076329702A5030267686 @default.
• W2076329702 hasAuthorship W2076329702A5033780024 @default.
• W2076329702 hasAuthorship W2076329702A5037540437 @default.
• W2076329702 hasAuthorship W2076329702A5039731517 @default.
• W2076329702 hasAuthorship W2076329702A5045621057 @default.
• W2076329702 hasAuthorship W2076329702A5047212574 @default.
• W2076329702 hasAuthorship W2076329702A5051610805 @default.
• W2076329702 hasAuthorship W2076329702A5052307736 @default.
• W2076329702 hasAuthorship W2076329702A5054656133 @default.
• W2076329702 hasAuthorship W2076329702A5056663920 @default.
• W2076329702 hasAuthorship W2076329702A5066237154 @default.
• W2076329702 hasAuthorship W2076329702A5070817744 @default.
• W2076329702 hasAuthorship W2076329702A5085708490 @default.
• W2076329702 hasBestOaLocation W20763297021 @default.
• W2076329702 hasConcept C104317684 @default.
• W2076329702 hasConcept C105795698 @default.
• W2076329702 hasConcept C106934330 @default.
• W2076329702 hasConcept C121332964 @default.
• W2076329702 hasConcept C122048520 @default.
• W2076329702 hasConcept C144024400 @default.
• W2076329702 hasConcept C149923435 @default.
• W2076329702 hasConcept C199360897 @default.
• W2076329702 hasConcept C2778334786 @default.
• W2076329702 hasConcept C2908647359 @default.
• W2076329702 hasConcept C33923547 @default.
• W2076329702 hasConcept C41008148 @default.
• W2076329702 hasConcept C44870925 @default.
• W2076329702 hasConcept C54355233 @default.
• W2076329702 hasConcept C68873052 @default.
• W2076329702 hasConcept C78458016 @default.
• W2076329702 hasConcept C81941488 @default.

• next