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- W2076333309 abstract "Extracellular Ca2+ concentration [Ca2+]o is vital for a number of processes varying from blood clotting to regulation membrane permeability and excitability. For this reason [Ca2+]o is under strict control of a complex homeostatic system that includes parathyroid glands, kidneys, bones and intestine. The extracellular Ca2+-sensing receptor is an essential component of this system, regulating parathyroid hormone secretion, Ca2+ (and Mg2+) excretion by the kidney, bone remodeling and Ca2+ reabsorption by the gastrointestinal tract. The Ca2+-sensing receptor is also present in organs without an obvious link with mineral ion metabolism. This review will describe the discovery of a novel class of ion-sensing receptor(s), receptor–effector coupling and the roles of the Ca2+-sensing receptor inside and outside the Ca2+o homeostatic system." @default.
- W2076333309 created "2016-06-24" @default.
- W2076333309 creator A5029497708 @default.
- W2076333309 creator A5062022173 @default.
- W2076333309 date "2002-07-01" @default.
- W2076333309 modified "2023-10-18" @default.
- W2076333309 title "Physiological and pharmacological agonists of the extracellular Ca2+-sensing receptor" @default.
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- W2076333309 doi "https://doi.org/10.1016/s0014-2999(02)01849-6" @default.
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