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- W2076336113 abstract "The serum levels of 25-hydroxycholecalciferol, 24,25-dihydroxycholecalciferol, and 1,25-dihydroxycholecalciferol were measured simulataneously in three groups of adults with different renal function: normal (n = 24), glomerular filtration rate (GFR) > 70 ml/min; moderately decreased (n = 15), GFR 5–35 ml/min, and severely decreased (n = 27), GFR < 5 ml/min. 25-hydroxycholecalciferol was normal in both patient groups with decreased renal function. 1,25-dihydroxycholecalciferol was halved in the group with moderately decreased renal function (p < 0.01) and severely decreased (almost undetectable) in the group with severely decreased renal function (p < 0.01). In contrast, 24,25-dihydroxycholecalciferol was normal in the group with moderately decreased renal function and only halved (p < 0.05) in the group with severely decreased renal function. These findings suggest extrarenal C-24 hydroxylase activity which may be stimulated by decreasing renal function, thus decreasing renal C-24 hydroxylase activity." @default.
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- W2076336113 date "1985-01-01" @default.
- W2076336113 modified "2023-10-18" @default.
- W2076336113 title "Serum Concentrations of Vitamin D Metabolites in Different Degrees of Impaired Renal Function" @default.
- W2076336113 doi "https://doi.org/10.1159/000183383" @default.
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