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• W2076338664 abstract "Autoradiographic studies were performed to investigate the changes in cellular proliferation of splenic cells after sham operation and 2/3 partial hepatectomy. Material and Methods: 54 female Wistar rats were hepatectomized and 27 rats were sham operated. The life span of the animals ranged between 12 hours and 31 days. One hour before sacrificing, the animals were injected intraperitoneally with 3H-thymidine (2.5 μCi/1g). Liver and spleen were embedded in paraffin and epoxy. In strippingfilm autoradiograms (Kodak, AR 10) a,nd in semithinsection autoradiograms (Eastman Kodak, NTB 2) labeling indices of the hepatocytes and Kupffer cells of the regenerating liver and of the cells in the white and red pulp as well as in the marginal zone of the spleen were measured. Results and Discussion After 2/3 partial hepatectomy there is a marked increase of proliferating, DNA synthezising basophilic blasts and basophilic and polychromatic erythroblasts in the red pulp of the spleen of rats during the first 5 to 10 days. After the fifth day the labeling index of the myelopoietic cells increases too. The curve of the percentages of radioactive labeled cells in the red pulp shows two peaks. The first can be observed after 24 hours and the second after 5 to 10 days. The percentages of labeled cells in the lymphatic mantle zone of the white pulp and in the marginal zone increase also during the first two postoperative days. This first maximum of labeled cells in all the zones of the spleen shows a close relationship to the maximum of proliferating DNA synthezising cells in the regenerating liver. The second peak in the red pulp is possibly caused by a nonspecific multifactorial stimulus such as operation stress, blood loss or inflammation during woundhealing. This proliferation enhancing effect in the spleen, especially on the erythropoietic cells, after partial hepatectomy, which produces a mild splenomegaly during the first 5 days, is more distinct than after sham operation, mechanical or thermical lesions on parenchymal organs. Von 71 ausgewachsenen weiblichen Wistar-Ratten (Durchschnittsgewicht 200 g) wurden 54 Tiere in üblicher Weise 2/3-teilhepatektomiert und 27 Tiere scheinoperiert, um die zelluläre Reaktion in der Milz autoradiographisch mit 3H-Thymidin an Stripping-film-Autoradiogrammen und Semidünnschnitt-Autoradiogrammen zu untersuchen. 10 Tiere dienten als Kontrollen. Nach 2/3-Teilhepatektomie kommt es innerhalb der ersten 5 Tage zu einer Verdoppelung der Milzgewichte. Die weiße Pulpa und die Marginalzone reagieren relativ gering auf den Eingriff einer 2/3-Teilhepatektomie, wobei die zelluläre Reaktion derjenigen nach mechanischen oder thermischen Läsionen an parenchymatösen Organen ähnelt. In der roten Pulpa zeigt sich dagegen eine erhebliche Proliferation hämatopoetischer Zellen insbesondere erythropoetischer Elemente. Als Ursache für die besonders in der roten Pulpa gesteigerten Zeilproliferation, die zweigipfelig verläuft, müssen neben einem unspezifischen Operationsstreß, einem wenn auch relativ geringen Blutverlust und entzündlichen Vorgängen auch Faktoren, die regulativ bei der Leberregeneration nach Teilhepatektomie wirksam sind, angenommen werden." @default.
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• W2076338664 date "1975-01-01" @default.
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• W2076338664 title "Zum zellulären Verhalten der Rattenmilz nach großem Parenchymverlust der Leber" @default.
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• W2076338664 doi "https://doi.org/10.1016/s0005-8165(75)80082-5" @default.
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