FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076347557> ?p ?o ?g. }

• W2076347557 endingPage "3762" @default.
• W2076347557 startingPage "3755" @default.
• W2076347557 abstract "Chemokines are mediators of innate and acquired immunity. CCL18, also designated pulmonary and activation-regulated chemokine (PARC), dendritic cell-derived CC chemokine-1 (DC-CK1), alternative macrophage activation-associated CC chemokine-1 (AMAC-1) and macrophage inflammatory protein-4 (MIP-4), was for the first time isolated from peripheral blood mononuclear cells (PBMC) and biochemically characterized. We found that CCL18/PARC protein is spontaneously secreted by PBMC and is selectively induced in PBMC by staphylococcal enterotoxins (SEA, SEB) and IL-4, but not by IFN-gamma and the CXCL8/IL-8 inducers lipopolysaccharide (LPS) or Concanavalin A. Human fibroblasts, chondrocytes and endothelial cells did not produce CCL18/PARC in response to inflammatory mediators such as measles virus, double-stranded RNA, LPS or IL-1beta, whereas up to 150 ng/ml of CCL2/MCP-1 was induced under these conditions. In synovial fluids from septic and rheumatoid arthritis patients, fourfold-enhanced CCL18/PARC levels (150 ng/ml) were detected compared to those in crystal-induced arthritis and osteoarthritis. In septic arthritis, the synovial levels of CCL18/PARC were fivefold higher than those of CXCL8/IL-8. Immunochemistry revealed CD68(+) monocytes/macrophages as the main CCL18/PARC-producing cell type in both PBMC and arthritic synovial tissue. In addition, CD1a(+) blood dendritic cells expressed CCL18/PARC. These findings suggest that monocytic cells respond to Gram-positive bacterial infection by the production of CCL18/PARC in the synovial cavity." @default.
• W2076347557 created "2016-06-24" @default.
• W2076347557 creator A5026098257 @default.
• W2076347557 creator A5043313288 @default.
• W2076347557 creator A5048493199 @default.
• W2076347557 creator A5060529637 @default.
• W2076347557 creator A5080389611 @default.
• W2076347557 creator A5084092941 @default.
• W2076347557 creator A5084134209 @default.
• W2076347557 creator A5086970621 @default.
• W2076347557 date "2001-12-01" @default.
• W2076347557 modified "2023-10-05" @default.
• W2076347557 title "Selective induction of CCL18/PARC by staphylococcal enterotoxins in mononuclear cells and enhanced levels in septic and rheumatoid arthritis" @default.
• W2076347557 cites W1521414677 @default.
• W2076347557 cites W1586288602 @default.
• W2076347557 cites W1919579956 @default.
• W2076347557 cites W1924532031 @default.
• W2076347557 cites W1978201079 @default.
• W2076347557 cites W1980325904 @default.
• W2076347557 cites W1986984711 @default.
• W2076347557 cites W2000350636 @default.
• W2076347557 cites W2000668139 @default.
• W2076347557 cites W2022665762 @default.
• W2076347557 cites W2028399398 @default.
• W2076347557 cites W2055526040 @default.
• W2076347557 cites W2098151091 @default.
• W2076347557 cites W2132309227 @default.
• W2076347557 cites W2166982025 @default.
• W2076347557 cites W4243315835 @default.
• W2076347557 cites W4313333678 @default.
• W2076347557 doi "https://doi.org/10.1002/1521-4141(200112)31:12<3755::aid-immu3755>3.0.co;2-o" @default.
• W2076347557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11745396" @default.
• W2076347557 hasPublicationYear "2001" @default.
• W2076347557 type Work @default.
• W2076347557 sameAs 2076347557 @default.
• W2076347557 citedByCount "58" @default.
• W2076347557 countsByYear W20763475572012 @default.
• W2076347557 countsByYear W20763475572013 @default.
• W2076347557 countsByYear W20763475572014 @default.
• W2076347557 countsByYear W20763475572015 @default.
• W2076347557 countsByYear W20763475572016 @default.
• W2076347557 countsByYear W20763475572017 @default.
• W2076347557 countsByYear W20763475572018 @default.
• W2076347557 countsByYear W20763475572022 @default.
• W2076347557 countsByYear W20763475572023 @default.
• W2076347557 crossrefType "journal-article" @default.
• W2076347557 hasAuthorship W2076347557A5026098257 @default.
• W2076347557 hasAuthorship W2076347557A5043313288 @default.
• W2076347557 hasAuthorship W2076347557A5048493199 @default.
• W2076347557 hasAuthorship W2076347557A5060529637 @default.
• W2076347557 hasAuthorship W2076347557A5080389611 @default.
• W2076347557 hasAuthorship W2076347557A5084092941 @default.
• W2076347557 hasAuthorship W2076347557A5084134209 @default.
• W2076347557 hasAuthorship W2076347557A5086970621 @default.
• W2076347557 hasConcept C13373296 @default.
• W2076347557 hasConcept C142724271 @default.
• W2076347557 hasConcept C157081693 @default.
• W2076347557 hasConcept C203014093 @default.
• W2076347557 hasConcept C204787440 @default.
• W2076347557 hasConcept C2776164576 @default.
• W2076347557 hasConcept C2776268809 @default.
• W2076347557 hasConcept C2776914184 @default.
• W2076347557 hasConcept C2778754761 @default.
• W2076347557 hasConcept C5858377 @default.
• W2076347557 hasConcept C68324877 @default.
• W2076347557 hasConcept C71924100 @default.
• W2076347557 hasConcept C86803240 @default.
• W2076347557 hasConceptScore W2076347557C13373296 @default.
• W2076347557 hasConceptScore W2076347557C142724271 @default.
• W2076347557 hasConceptScore W2076347557C157081693 @default.
• W2076347557 hasConceptScore W2076347557C203014093 @default.
• W2076347557 hasConceptScore W2076347557C204787440 @default.
• W2076347557 hasConceptScore W2076347557C2776164576 @default.
• W2076347557 hasConceptScore W2076347557C2776268809 @default.
• W2076347557 hasConceptScore W2076347557C2776914184 @default.
• W2076347557 hasConceptScore W2076347557C2778754761 @default.
• W2076347557 hasConceptScore W2076347557C5858377 @default.
• W2076347557 hasConceptScore W2076347557C68324877 @default.
• W2076347557 hasConceptScore W2076347557C71924100 @default.
• W2076347557 hasConceptScore W2076347557C86803240 @default.
• W2076347557 hasIssue "12" @default.
• W2076347557 hasLocation W20763475571 @default.
• W2076347557 hasLocation W20763475572 @default.
• W2076347557 hasOpenAccess W2076347557 @default.
• W2076347557 hasPrimaryLocation W20763475571 @default.
• W2076347557 hasRelatedWork W2060839308 @default.
• W2076347557 hasRelatedWork W2070463916 @default.
• W2076347557 hasRelatedWork W2071670587 @default.
• W2076347557 hasRelatedWork W2120026087 @default.
• W2076347557 hasRelatedWork W2131907262 @default.
• W2076347557 hasRelatedWork W2134965930 @default.
• W2076347557 hasRelatedWork W2383425629 @default.
• W2076347557 hasRelatedWork W2471318345 @default.
• W2076347557 hasRelatedWork W2740619893 @default.
• W2076347557 hasRelatedWork W4240994728 @default.
• W2076347557 hasVolume "31" @default.
• W2076347557 isParatext "false" @default.
• W2076347557 isRetracted "false" @default.

• next