Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076350082> ?p ?o ?g. }
- W2076350082 endingPage "63" @default.
- W2076350082 startingPage "57" @default.
- W2076350082 abstract "3,3-Di-methyl-azetidin-2-ones were identified as potent and selective 11β-HSD1 inhibitors against the human and mouse forms of the enzyme. Structure guided optimisation of LLE was conducted, utilising a key polar interaction and identifying stereochemical preference for the 4S isomer. Metabolic stability was improved to afford oral exposure, providing tool compounds suitable for pre-clinical evaluation." @default.
- W2076350082 created "2016-06-24" @default.
- W2076350082 creator A5008873535 @default.
- W2076350082 creator A5013571136 @default.
- W2076350082 creator A5016152005 @default.
- W2076350082 creator A5026167637 @default.
- W2076350082 creator A5027171852 @default.
- W2076350082 creator A5029194654 @default.
- W2076350082 creator A5030572077 @default.
- W2076350082 creator A5036792004 @default.
- W2076350082 creator A5050783675 @default.
- W2076350082 creator A5054713500 @default.
- W2076350082 creator A5058181236 @default.
- W2076350082 creator A5058513759 @default.
- W2076350082 creator A5059620686 @default.
- W2076350082 creator A5063447756 @default.
- W2076350082 creator A5086631777 @default.
- W2076350082 creator A5087521201 @default.
- W2076350082 creator A5088744518 @default.
- W2076350082 date "2014-01-01" @default.
- W2076350082 modified "2023-10-07" @default.
- W2076350082 title "Identification and optimisation of 3,3-dimethyl-azetidin-2-ones as potent and selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)" @default.
- W2076350082 cites W1966761489 @default.
- W2076350082 cites W1968839618 @default.
- W2076350082 cites W1972693920 @default.
- W2076350082 cites W1976973182 @default.
- W2076350082 cites W1999368051 @default.
- W2076350082 cites W2009423060 @default.
- W2076350082 cites W2009790358 @default.
- W2076350082 cites W2016125985 @default.
- W2076350082 cites W2026157726 @default.
- W2076350082 cites W2028977768 @default.
- W2076350082 cites W2029646361 @default.
- W2076350082 cites W2032798922 @default.
- W2076350082 cites W2046885685 @default.
- W2076350082 cites W2050673609 @default.
- W2076350082 cites W2051601643 @default.
- W2076350082 cites W2052787253 @default.
- W2076350082 cites W2053815237 @default.
- W2076350082 cites W2061962280 @default.
- W2076350082 cites W2062458432 @default.
- W2076350082 cites W2066356327 @default.
- W2076350082 cites W2080182898 @default.
- W2076350082 cites W2101439149 @default.
- W2076350082 cites W2109018676 @default.
- W2076350082 cites W2114348416 @default.
- W2076350082 cites W2116828140 @default.
- W2076350082 cites W2123289485 @default.
- W2076350082 cites W2140044937 @default.
- W2076350082 cites W2145258378 @default.
- W2076350082 cites W2150654293 @default.
- W2076350082 cites W2324222779 @default.
- W2076350082 cites W2952563776 @default.
- W2076350082 doi "https://doi.org/10.1039/c3md00234a" @default.
- W2076350082 hasPublicationYear "2014" @default.
- W2076350082 type Work @default.
- W2076350082 sameAs 2076350082 @default.
- W2076350082 citedByCount "6" @default.
- W2076350082 countsByYear W20763500822013 @default.
- W2076350082 countsByYear W20763500822018 @default.
- W2076350082 countsByYear W20763500822020 @default.
- W2076350082 countsByYear W20763500822021 @default.
- W2076350082 crossrefType "journal-article" @default.
- W2076350082 hasAuthorship W2076350082A5008873535 @default.
- W2076350082 hasAuthorship W2076350082A5013571136 @default.
- W2076350082 hasAuthorship W2076350082A5016152005 @default.
- W2076350082 hasAuthorship W2076350082A5026167637 @default.
- W2076350082 hasAuthorship W2076350082A5027171852 @default.
- W2076350082 hasAuthorship W2076350082A5029194654 @default.
- W2076350082 hasAuthorship W2076350082A5030572077 @default.
- W2076350082 hasAuthorship W2076350082A5036792004 @default.
- W2076350082 hasAuthorship W2076350082A5050783675 @default.
- W2076350082 hasAuthorship W2076350082A5054713500 @default.
- W2076350082 hasAuthorship W2076350082A5058181236 @default.
- W2076350082 hasAuthorship W2076350082A5058513759 @default.
- W2076350082 hasAuthorship W2076350082A5059620686 @default.
- W2076350082 hasAuthorship W2076350082A5063447756 @default.
- W2076350082 hasAuthorship W2076350082A5086631777 @default.
- W2076350082 hasAuthorship W2076350082A5087521201 @default.
- W2076350082 hasAuthorship W2076350082A5088744518 @default.
- W2076350082 hasConcept C116834253 @default.
- W2076350082 hasConcept C166075782 @default.
- W2076350082 hasConcept C181199279 @default.
- W2076350082 hasConcept C185592680 @default.
- W2076350082 hasConcept C202751555 @default.
- W2076350082 hasConcept C21951064 @default.
- W2076350082 hasConcept C2776317432 @default.
- W2076350082 hasConcept C2781067048 @default.
- W2076350082 hasConcept C2991874392 @default.
- W2076350082 hasConcept C55493867 @default.
- W2076350082 hasConcept C59822182 @default.
- W2076350082 hasConcept C70721500 @default.
- W2076350082 hasConcept C71240020 @default.
- W2076350082 hasConcept C86803240 @default.
- W2076350082 hasConceptScore W2076350082C116834253 @default.
- W2076350082 hasConceptScore W2076350082C166075782 @default.
- W2076350082 hasConceptScore W2076350082C181199279 @default.
- W2076350082 hasConceptScore W2076350082C185592680 @default.