Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076352025> ?p ?o ?g. }
- W2076352025 endingPage "3162" @default.
- W2076352025 startingPage "3155" @default.
- W2076352025 abstract "Abstract Multiple myeloma (MM) is an incurable plasma cell malignancy with poor outcome. The most promising therapeutic options currently available are combinations of transplantation, targeted pharmacotherapy, and immunotherapy. Cell-based immunotherapy after hematopoietic stem-cell transplantation has been attempted, but with limited efficacy. Natural killer (NK) cells are interesting candidates for new means of immunotherapy; however, their potential clinical use in MM has not been extensively studied. Here, we explored the possibility of expanding NK cells from the peripheral blood of 7 newly diagnosed, untreated MM patients, using good manufacturing practice (GMP)–compliant components. After 20 days of culture, the number of NK cells from these patients had expanded on average 1600-fold. Moreover, expanded NK cells showed significant cytotoxicity against primary autologous MM cells, yet retained their tolerance against nonmalignant cells. Based on these findings, we propose that autologous NK cells expanded ex vivo deserve further attention as a possible new treatment modality for MM." @default.
- W2076352025 created "2016-06-24" @default.
- W2076352025 creator A5002440578 @default.
- W2076352025 creator A5014322334 @default.
- W2076352025 creator A5016321140 @default.
- W2076352025 creator A5044043535 @default.
- W2076352025 creator A5045493438 @default.
- W2076352025 creator A5049230560 @default.
- W2076352025 creator A5061888725 @default.
- W2076352025 creator A5066284854 @default.
- W2076352025 creator A5073119482 @default.
- W2076352025 creator A5091546357 @default.
- W2076352025 date "2008-03-15" @default.
- W2076352025 modified "2023-10-16" @default.
- W2076352025 title "Autologous antitumor activity by NK cells expanded from myeloma patients using GMP-compliant components" @default.
- W2076352025 cites W1514212547 @default.
- W2076352025 cites W1533843272 @default.
- W2076352025 cites W1583322496 @default.
- W2076352025 cites W1959932718 @default.
- W2076352025 cites W1969349875 @default.
- W2076352025 cites W1971712854 @default.
- W2076352025 cites W1979120529 @default.
- W2076352025 cites W1984534203 @default.
- W2076352025 cites W1992908671 @default.
- W2076352025 cites W1996445917 @default.
- W2076352025 cites W2001012146 @default.
- W2076352025 cites W2007825988 @default.
- W2076352025 cites W2022069273 @default.
- W2076352025 cites W2023674080 @default.
- W2076352025 cites W2031403346 @default.
- W2076352025 cites W2033107431 @default.
- W2076352025 cites W2033225545 @default.
- W2076352025 cites W2058475776 @default.
- W2076352025 cites W2059354338 @default.
- W2076352025 cites W2060439989 @default.
- W2076352025 cites W2063022052 @default.
- W2076352025 cites W2073643201 @default.
- W2076352025 cites W2083426483 @default.
- W2076352025 cites W2086332804 @default.
- W2076352025 cites W2087576224 @default.
- W2076352025 cites W2092183118 @default.
- W2076352025 cites W2096449627 @default.
- W2076352025 cites W2104494161 @default.
- W2076352025 cites W2104794630 @default.
- W2076352025 cites W2119810076 @default.
- W2076352025 cites W2126507406 @default.
- W2076352025 cites W2128659799 @default.
- W2076352025 cites W2129278872 @default.
- W2076352025 cites W2130649175 @default.
- W2076352025 cites W2145651125 @default.
- W2076352025 cites W2149232375 @default.
- W2076352025 cites W2149634568 @default.
- W2076352025 cites W2152105313 @default.
- W2076352025 cites W2165813814 @default.
- W2076352025 cites W2165922002 @default.
- W2076352025 cites W2171709048 @default.
- W2076352025 cites W2306701420 @default.
- W2076352025 doi "https://doi.org/10.1182/blood-2007-09-110312" @default.
- W2076352025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18192509" @default.
- W2076352025 hasPublicationYear "2008" @default.
- W2076352025 type Work @default.
- W2076352025 sameAs 2076352025 @default.
- W2076352025 citedByCount "169" @default.
- W2076352025 countsByYear W20763520252012 @default.
- W2076352025 countsByYear W20763520252013 @default.
- W2076352025 countsByYear W20763520252014 @default.
- W2076352025 countsByYear W20763520252015 @default.
- W2076352025 countsByYear W20763520252016 @default.
- W2076352025 countsByYear W20763520252017 @default.
- W2076352025 countsByYear W20763520252018 @default.
- W2076352025 countsByYear W20763520252019 @default.
- W2076352025 countsByYear W20763520252020 @default.
- W2076352025 countsByYear W20763520252021 @default.
- W2076352025 countsByYear W20763520252022 @default.
- W2076352025 countsByYear W20763520252023 @default.
- W2076352025 crossrefType "journal-article" @default.
- W2076352025 hasAuthorship W2076352025A5002440578 @default.
- W2076352025 hasAuthorship W2076352025A5014322334 @default.
- W2076352025 hasAuthorship W2076352025A5016321140 @default.
- W2076352025 hasAuthorship W2076352025A5044043535 @default.
- W2076352025 hasAuthorship W2076352025A5045493438 @default.
- W2076352025 hasAuthorship W2076352025A5049230560 @default.
- W2076352025 hasAuthorship W2076352025A5061888725 @default.
- W2076352025 hasAuthorship W2076352025A5066284854 @default.
- W2076352025 hasAuthorship W2076352025A5073119482 @default.
- W2076352025 hasAuthorship W2076352025A5091546357 @default.
- W2076352025 hasBestOaLocation W20763520251 @default.
- W2076352025 hasConcept C10882517 @default.
- W2076352025 hasConcept C126322002 @default.
- W2076352025 hasConcept C150903083 @default.
- W2076352025 hasConcept C203014093 @default.
- W2076352025 hasConcept C207001950 @default.
- W2076352025 hasConcept C26291073 @default.
- W2076352025 hasConcept C2776364478 @default.
- W2076352025 hasConcept C2777408962 @default.
- W2076352025 hasConcept C2777701055 @default.
- W2076352025 hasConcept C28328180 @default.
- W2076352025 hasConcept C2911091166 @default.