FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076354639> ?p ?o ?g. }

• W2076354639 endingPage "115" @default.
• W2076354639 startingPage "103" @default.
• W2076354639 abstract "The intractable process of fibrosis underlies the pathogenesis of systemic sclerosis (SSc) and other diseases, and in aggregate contributes to 45% of deaths worldwide. Because currently there is no effective anti-fibrotic therapy, a better understanding of the pathways and cellular differentiation programs underlying fibrosis are needed. Emerging evidence points to a fundamental role of the nuclear hormone receptor peroxisome proliferator activated receptor-γ (PPAR-γ) in modulating fibrogenesis. While PPAR-γ has long been known to be important in lipid metabolism and in glucose homeostasis, its role in regulating mesenchymal cell biology and its association with pathological fibrosis had not been appreciated until recently. This article highlights recent studies revealing a consistent association of fibrosis with aberrant PPAR-γ expression and activity in various forms of human fibrosis and in rodent models, and reviews studies linking genetic manipulation of the PPAR-γ pathway in rodents and fibrosis. We survey the broad range of anti-fibrotic activities associated with PPAR-γ and the underlying mechanisms. We also summarize the emerging data linking PPAR-γ dysfunction and pulmonary arterial hypertension (PAH), which together with fibrosis is responsible for the mortality in patients in SSc. Finally, we consider current and potential future strategies for targeting PPAR-γ activity or expression as a therapy for controlling fibrosis." @default.
• W2076354639 created "2016-06-24" @default.
• W2076354639 creator A5012966437 @default.
• W2076354639 creator A5033986825 @default.
• W2076354639 creator A5039726678 @default.
• W2076354639 creator A5068704522 @default.
• W2076354639 date "2012-06-15" @default.
• W2076354639 modified "2023-10-18" @default.
• W2076354639 title "Regulation of Matrix Remodeling by Peroxisome Proliferator-Activated Receptor-γ: A Novel Link Between Metabolism and Fibrogenesis" @default.
• W2076354639 cites W1490068297 @default.
• W2076354639 cites W1524650585 @default.
• W2076354639 cites W1623983039 @default.
• W2076354639 cites W1748498732 @default.
• W2076354639 cites W1833585487 @default.
• W2076354639 cites W1965049982 @default.
• W2076354639 cites W1966975625 @default.
• W2076354639 cites W1967131493 @default.
• W2076354639 cites W1968683832 @default.
• W2076354639 cites W1968703258 @default.
• W2076354639 cites W1970602356 @default.
• W2076354639 cites W1970779494 @default.
• W2076354639 cites W1977666051 @default.
• W2076354639 cites W1981654839 @default.
• W2076354639 cites W1981670717 @default.
• W2076354639 cites W1981904021 @default.
• W2076354639 cites W1984939059 @default.
• W2076354639 cites W1985414680 @default.
• W2076354639 cites W1989386822 @default.
• W2076354639 cites W1991127474 @default.
• W2076354639 cites W1991866614 @default.
• W2076354639 cites W1993125863 @default.
• W2076354639 cites W1994713876 @default.
• W2076354639 cites W1994908701 @default.
• W2076354639 cites W1995312154 @default.
• W2076354639 cites W1995398218 @default.
• W2076354639 cites W1995606131 @default.
• W2076354639 cites W1999113566 @default.
• W2076354639 cites W2001290163 @default.
• W2076354639 cites W2002519246 @default.
• W2076354639 cites W2007381747 @default.
• W2076354639 cites W2008680449 @default.
• W2076354639 cites W2008683618 @default.
• W2076354639 cites W2009036920 @default.
• W2076354639 cites W2010221831 @default.
• W2076354639 cites W2012580599 @default.
• W2076354639 cites W2016443141 @default.
• W2076354639 cites W2016611373 @default.
• W2076354639 cites W2016728909 @default.
• W2076354639 cites W2018185237 @default.
• W2076354639 cites W2021436633 @default.
• W2076354639 cites W2024059588 @default.
• W2076354639 cites W2025657436 @default.
• W2076354639 cites W2026356057 @default.
• W2076354639 cites W2029506882 @default.
• W2076354639 cites W2032722121 @default.
• W2076354639 cites W2033204507 @default.
• W2076354639 cites W2033653350 @default.
• W2076354639 cites W2034345866 @default.
• W2076354639 cites W2036303156 @default.
• W2076354639 cites W2042605274 @default.
• W2076354639 cites W2043129312 @default.
• W2076354639 cites W2043898709 @default.
• W2076354639 cites W2051303265 @default.
• W2076354639 cites W2052931002 @default.
• W2076354639 cites W2053780981 @default.
• W2076354639 cites W2055125978 @default.
• W2076354639 cites W2057947695 @default.
• W2076354639 cites W2059895383 @default.
• W2076354639 cites W2061423598 @default.
• W2076354639 cites W2063099598 @default.
• W2076354639 cites W2063502039 @default.
• W2076354639 cites W2064326876 @default.
• W2076354639 cites W2065667627 @default.
• W2076354639 cites W2066727736 @default.
• W2076354639 cites W2069775532 @default.
• W2076354639 cites W2070437540 @default.
• W2076354639 cites W2071077259 @default.
• W2076354639 cites W2071802200 @default.
• W2076354639 cites W2073482601 @default.
• W2076354639 cites W2073874786 @default.
• W2076354639 cites W2076415587 @default.
• W2076354639 cites W2078424139 @default.
• W2076354639 cites W2079610423 @default.
• W2076354639 cites W2080345081 @default.
• W2076354639 cites W2083360850 @default.
• W2076354639 cites W2087323626 @default.
• W2076354639 cites W2087613795 @default.
• W2076354639 cites W2087788915 @default.
• W2076354639 cites W2090466279 @default.
• W2076354639 cites W2091466360 @default.
• W2076354639 cites W2091557699 @default.
• W2076354639 cites W2091673549 @default.
• W2076354639 cites W2095033662 @default.
• W2076354639 cites W2097059107 @default.
• W2076354639 cites W2097511872 @default.
• W2076354639 cites W2099164108 @default.
• W2076354639 cites W2099274614 @default.
• W2076354639 cites W2102663269 @default.

• next