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- W2076355513 abstract "The expression of a number of genes was measured in P1798 cells treated for various periods of time with 0.1 μM dexamethasone. Thymidine kinase (TK) activity decreased under these conditions with 50% inhibition achieved within approximately 8 h. Decreased TK activity was associated with reduced abundance of TK mRNA. Analysis of nuclear transcription indicated that this was attribuable to a decrease in the number of RNA polymerase II molecules engaged in transcription of the TK gene. With respect to TK, there was an overall correlation between enzyme activity, mRNA, and nuclear transcription. The data are consistent with the hypothesis that glucocorticoid inhibition of expression of TK is primarily due to inhibition of transcription. Transcription of the TK gene was also reduced by greater than 90% after inhibition of protein synthesis for 6 h. This suggests that transcription of this gene requires a protein of short biological half-life. It is proposed that this hypothetical transcription factor is regulated by glucocorticoids." @default.
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- W2076355513 date "1988-01-01" @default.
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- W2076355513 title "Glucocorticoid Regulation of the Genes Encoding Thymidine Kinase, Thymidylate Synthase, and Ornithine Decarboxylase in P1798 Cells" @default.
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- W2076355513 doi "https://doi.org/10.1210/mend-2-1-78" @default.
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