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• W2076356585 abstract "This study explores the roles of genome copy number abnormalities (CNAs) in breast cancer pathophysiology by identifying associations between recurrent CNAs, gene expression, and clinical outcome in a set of aggressively treated early-stage breast tumors. It shows that the recurrent CNAs differ between tumor subtypes defined by expression pattern and that stratification of patients according to outcome can be improved by measuring both expression and copy number, especially high-level amplification. Sixty-six genes deregulated by the high-level amplifications are potential therapeutic targets. Nine of these (FGFR1, IKBKB, ERBB2, PROCC, ADAM9, FNTA, ACACA, PNMT, and NR1D1) are considered druggable. Low-level CNAs appear to contribute to cancer progression by altering RNA and cellular metabolism." @default.
• W2076356585 created "2016-06-24" @default.
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• W2076356585 date "2006-12-01" @default.
• W2076356585 modified "2023-10-18" @default.
• W2076356585 title "Genomic and transcriptional aberrations linked to breast cancer pathophysiologies" @default.
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• W2076356585 doi "https://doi.org/10.1016/j.ccr.2006.10.009" @default.
• W2076356585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17157792" @default.

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