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• W2076356763 abstract "Regenerating rat liver microsomes contain a β-d-galactoside α-(2→3)- and a 2-acetamido-2-deoxy-β-d-glucoside α-(2→6)-sialyltransferase that are involved in the synthesis of the terminal α-NeuAc-(2→3)-β-d-Galp-(1→3)-α-[NeuAc-(2→6)]-β-d-GlcpNAc-(1→R) group occurring in human milk oligossacharides and the glycan chains of several N-glycoproteins. Analysis by liquid chromatography and methylation of the products of sialylation obtained when lacto-N-tetraose [β-d-Galp-(1→3)-β-d-GlcpNAc-(1→3)-β-d-Galp-(1→4)-d-Glc] was used as a substrate in the incubations in vitro indicated that the disialylated sequence is formed for >95% through the tetrasaccharide α-NeuAc-(2→3)-β-d-Gal-(1→3)-β-d-GlcNAc-(1→3)-β-d-Gal-(1→4)-d-Glc as one of two possible intermediates. This indicates that in the synthesis of the disialylated sequence the α-(2→3)- and the α-(2-ar6)-sialyltransferase act in a highly preferred order in which the α-(2→3) enzyme acts first. This order is imposed by the specificity of the α-(2→6)-sialyltransferase, which requires an α-NeuAc-(2→3)-β-d-Gal-(1→3)-β-d-GlcNAc-(1→R) sequence for optimal activity, and shows very low and no activity with β-d-Gal-(1→3)-β-d-GlcNAc-(1→R) and β-d-GlcNAc-(1→R) acceptor structures, respectively. Results obtained with normal rat, fetal calf, rabbit and human liver, and human placenta indicated that very similar or identical sialyltransferases occur in these tissues. It is suggested that these enzymes differ from the sialyltransferases that previously had been identified in fetal calf liver and human placenta." @default.
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• W2076356763 date "1986-06-01" @default.
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• W2076356763 title "Biosynthesis of disialylated β-d-galactopyranosyl-(1→3)-2-acetamido-2-deoxy-β-d-glucopyranosyl oligosaccharide chains. Identification of a β-d-galactoside α-(2→3)- and a 2-acetamido-2-deoxy-β-d-glucoside α-(2→6)-sialyltransferase in regenerating rat liver and other tissues" @default.
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• W2076356763 doi "https://doi.org/10.1016/s0008-6215(00)90371-9" @default.
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