FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076357323> ?p ?o ?g. }

• W2076357323 endingPage "977" @default.
• W2076357323 startingPage "970" @default.
• W2076357323 abstract "Mice lacking orexin/hypocretin signaling have sudden episodes of atonia and paralysis during active wakefulness. These events strongly resemble cataplexy, episodes of sudden muscle weakness triggered by strong positive emotions in people with narcolepsy, but it remains unknown whether murine cataplexy is triggered by positive emotions. To determine whether positive emotions elicit murine cataplexy, we placed orexin knockout (KO) mice on a scheduled feeding protocol with regular or highly palatable food. Baseline sleep/wake behavior was recorded with ad libitum regular chow. Mice were then placed on a scheduled feeding protocol in which they received 60% of their normal amount of chow 3 h after dark onset for the next 10 days. Wild-type and KO mice rapidly entrained to scheduled feeding with regular chow, with more wake and locomotor activity prior to the feeding time. On day 10 of scheduled feeding, orexin KO mice had slightly more cataplexy during the food-anticipation period and more cataplexy in the second half of the dark period, when they may have been foraging for residual food. To test whether more palatable food increases cataplexy, mice were then switched to scheduled feeding with an isocaloric amount of Froot Loops, a food often used as a reward in behavioral studies. With this highly palatable food, orexin KO mice had much more cataplexy during the food-anticipation period and throughout the dark period. The increase in cataplexy with scheduled feeding, especially with highly palatable food, suggests that positive emotions may trigger cataplexy in mice, just as in people with narcolepsy. Establishing this connection helps validate orexin KO mice as an excellent model of human narcolepsy and provides an opportunity to better understand the mechanisms that trigger cataplexy." @default.
• W2076357323 created "2016-06-24" @default.
• W2076357323 creator A5005536434 @default.
• W2076357323 creator A5008766966 @default.
• W2076357323 creator A5029480014 @default.
• W2076357323 creator A5030287146 @default.
• W2076357323 creator A5081084459 @default.
• W2076357323 date "2009-07-01" @default.
• W2076357323 modified "2023-10-02" @default.
• W2076357323 title "Feeding-elicited cataplexy in orexin knockout mice" @default.
• W2076357323 cites W1519232679 @default.
• W2076357323 cites W1829186012 @default.
• W2076357323 cites W1938381539 @default.
• W2076357323 cites W1967884630 @default.
• W2076357323 cites W1973597713 @default.
• W2076357323 cites W1975748128 @default.
• W2076357323 cites W1977320288 @default.
• W2076357323 cites W1983298714 @default.
• W2076357323 cites W1985526077 @default.
• W2076357323 cites W1992895646 @default.
• W2076357323 cites W1993068187 @default.
• W2076357323 cites W1998101177 @default.
• W2076357323 cites W2003166239 @default.
• W2076357323 cites W2018373025 @default.
• W2076357323 cites W2027571475 @default.
• W2076357323 cites W2030324378 @default.
• W2076357323 cites W2030681878 @default.
• W2076357323 cites W2032414668 @default.
• W2076357323 cites W2041321054 @default.
• W2076357323 cites W2044393257 @default.
• W2076357323 cites W2059728043 @default.
• W2076357323 cites W2061886084 @default.
• W2076357323 cites W2066511972 @default.
• W2076357323 cites W2072154498 @default.
• W2076357323 cites W2115070641 @default.
• W2076357323 cites W2115861749 @default.
• W2076357323 cites W2119270136 @default.
• W2076357323 cites W2127225700 @default.
• W2076357323 cites W2128337910 @default.
• W2076357323 cites W2134923404 @default.
• W2076357323 cites W2143609607 @default.
• W2076357323 cites W2150515709 @default.
• W2076357323 cites W2152515205 @default.
• W2076357323 cites W2159953069 @default.
• W2076357323 cites W2165996850 @default.
• W2076357323 cites W2167119018 @default.
• W2076357323 cites W2169014479 @default.
• W2076357323 cites W2171125703 @default.
• W2076357323 cites W4296220318 @default.
• W2076357323 cites W4321429251 @default.
• W2076357323 cites W45849756 @default.
• W2076357323 doi "https://doi.org/10.1016/j.neuroscience.2009.04.007" @default.
• W2076357323 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2743520" @default.
• W2076357323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19362119" @default.
• W2076357323 hasPublicationYear "2009" @default.
• W2076357323 type Work @default.
• W2076357323 sameAs 2076357323 @default.
• W2076357323 citedByCount "66" @default.
• W2076357323 countsByYear W20763573232012 @default.
• W2076357323 countsByYear W20763573232013 @default.
• W2076357323 countsByYear W20763573232014 @default.
• W2076357323 countsByYear W20763573232015 @default.
• W2076357323 countsByYear W20763573232016 @default.
• W2076357323 countsByYear W20763573232017 @default.
• W2076357323 countsByYear W20763573232018 @default.
• W2076357323 countsByYear W20763573232019 @default.
• W2076357323 countsByYear W20763573232020 @default.
• W2076357323 countsByYear W20763573232021 @default.
• W2076357323 countsByYear W20763573232022 @default.
• W2076357323 countsByYear W20763573232023 @default.
• W2076357323 crossrefType "journal-article" @default.
• W2076357323 hasAuthorship W2076357323A5005536434 @default.
• W2076357323 hasAuthorship W2076357323A5008766966 @default.
• W2076357323 hasAuthorship W2076357323A5029480014 @default.
• W2076357323 hasAuthorship W2076357323A5030287146 @default.
• W2076357323 hasAuthorship W2076357323A5081084459 @default.
• W2076357323 hasBestOaLocation W20763573232 @default.
• W2076357323 hasConcept C118303440 @default.
• W2076357323 hasConcept C126322002 @default.
• W2076357323 hasConcept C134018914 @default.
• W2076357323 hasConcept C15744967 @default.
• W2076357323 hasConcept C16568411 @default.
• W2076357323 hasConcept C169760540 @default.
• W2076357323 hasConcept C170493617 @default.
• W2076357323 hasConcept C2779320081 @default.
• W2076357323 hasConcept C2779494582 @default.
• W2076357323 hasConcept C2779680196 @default.
• W2076357323 hasConcept C2780163352 @default.
• W2076357323 hasConcept C522805319 @default.
• W2076357323 hasConcept C71924100 @default.
• W2076357323 hasConceptScore W2076357323C118303440 @default.
• W2076357323 hasConceptScore W2076357323C126322002 @default.
• W2076357323 hasConceptScore W2076357323C134018914 @default.
• W2076357323 hasConceptScore W2076357323C15744967 @default.
• W2076357323 hasConceptScore W2076357323C16568411 @default.
• W2076357323 hasConceptScore W2076357323C169760540 @default.
• W2076357323 hasConceptScore W2076357323C170493617 @default.
• W2076357323 hasConceptScore W2076357323C2779320081 @default.

• next