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• W2076363535 abstract "The Australian sheep blowfly Lucilia cuprina (Wiedemann) is a major pest of sheep in Australia and New Zealand. From the 1960s to the 1980s there was a major effort to develop field female killing or FFK strains of L. cuprina that could be used for a cost-effective genetic control program. The FFK strains carried eye color mutations that were lethal to females in the field but not under conditions in the mass rearing facility. Males did not die in the field as normal copies of the eye color genes had been translocated to the Y chromosome and an autosome. Although the FFK strains showed some promise in field tests, a genetic control program in mainland Australia was never implemented for several reasons including instability of the FFK strains during mass rearing. A stable transgenic strain of L. cuprina that carried one or more dominant repressible female lethal genes offered the potential for efficient genetic control of blowfly populations. Here I review our research on tetracycline-repressible female lethal genetic systems, Lucilia germ-line transformation and sex determination genes that ultimately led to the successful development of transgenic male-only strains of L. cuprina. The technology developed for L. cuprina should be directly transferable to other blowfly livestock pests including L. sericata and the New World and Old World screwworm. 29." @default.
• W2076363535 created "2016-06-24" @default.
• W2076363535 creator A5028222365 @default.
• W2076363535 date "2014-12-01" @default.
• W2076363535 modified "2023-10-09" @default.
• W2076363535 title "Development and evaluation of male-only strains of the Australian sheep blowfly, Lucilia cuprina" @default.
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• W2076363535 doi "https://doi.org/10.1186/1471-2156-15-s2-s3" @default.
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