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• W2076367028 abstract "Previous studies have shown that immature but not mature astrocytes have the capacity to suppress glial scar formation and enhance axon outgrowth when transplanted into the adult mouse brain. We report here that glial scar formation is suppressed following transplantation of purified immature but not mature cultured type-1 rat cortical astrocytes into the adult rat brain. To examine the fate of transplanted cells, cultured astrocytes were labeled with either fluorescent beads or BSA-conjugated colloidal gold and traced after transplantation using both light and electron microscopy. While both immature and mature astrocytes survived transplantation, mature astrocytes appeared more susceptible to phagocytosis by cells of the immune system than immature astrocytes. Furthermore, while mature astrocytes were restricted to the region of the implant, immature astrocytes migrated into the surrounding CNS and became closely associated with host blood vessels. Such blood vessels were impermeable to the diffusion of systematically applied Evans blue dye. To determine whether immature astrocytes were intrinsically more motile than mature astrocytes, their rate of translocation was compared in vitro. Immature astrocytes translocated more than twice as fast as mature astrocytes. This ability of immature astrocytes to translocate throughout the host CNS and become associated with blood vessels may be a major factor in their ability to suppress glial scar formation in the adult animal." @default.
• W2076367028 created "2016-06-24" @default.
• W2076367028 creator A5011097362 @default.
• W2076367028 creator A5030332501 @default.
• W2076367028 date "1991-03-01" @default.
• W2076367028 modified "2023-09-26" @default.
• W2076367028 title "Immature type-1 astrocytes suppress glial scar formation, are motile and interact with blood vessels" @default.
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• W2076367028 doi "https://doi.org/10.1016/0006-8993(91)91054-5" @default.
• W2076367028 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2054666" @default.
• W2076367028 hasPublicationYear "1991" @default.
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