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• W2076367684 startingPage "119" @default.
• W2076367684 abstract "To investigate the effectiveness of high-dose, curative radiotherapy (RT) given alone in technically operable, but medically inoperable, patients with early-stage (I–II) non-small-cell lung cancer (NSCLC). Computerized and manual searches were done to identify published reports dealing with curative RT for NSCLC. Relevant studies were identified and the information provided therein was extracted regarding patient and treatment characteristics, treatment outcome, and various pretreatment and treatment-related factors influencing outcome, as well as toxicity and quality-of-life issues. Although a large variation of pretreatment and treatment characteristics was noted in the available studies, a median survival time of >30 months and a 5-year survival rate of up to 30% had been achieved. Accumulated experience seems to suggest that doses of at least 65 Gy with standard fractionation, or its equivalent when altered fractionation is used, are necessary for control of NSCLC. Smaller tumors seem to have a favorable prognosis, and the issue of elective nodal RT continues to be controversial. Analyses of patterns of failure have clearly identified local failure as the predominant pattern. Although a number of potential pretreatment patient- and tumor-related prognostic factors have been examined, none has been shown to clearly influence survival. Toxicity was usually low, but very high doses (e.g., 80 Gy) given with a conventional approach may carry a risk of an excessive rate of side effects. High-dose, curative RT is an effective treatment modality in technically operable, but medically inoperable, patients with early-stage NSCLC." @default.
• W2076367684 created "2016-06-24" @default.
• W2076367684 creator A5029197290 @default.
• W2076367684 creator A5058609591 @default.
• W2076367684 creator A5076463194 @default.
• W2076367684 date "2002-09-01" @default.
• W2076367684 modified "2023-09-27" @default.
• W2076367684 title "Radiotherapy alone in technically operable, medically inoperable, early-stage (I/II) non-small-cell lung cancer" @default.
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