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• W2076372887 endingPage "830" @default.
• W2076372887 startingPage "824" @default.
• W2076372887 abstract "In tumor cells from virtually all patients with chronic myelogenous leukemia, the Philadelphia chromosome, a fusion of chromosomes 9 and 22, directs the synthesis of the P210bcr/abl protein. The protein-tyrosine kinase activity and hybrid structure of P210bcr/abl are similar to the oncogene product of the Abelson murine leukemia virus, P160gag/v-abl, which induces acute lymphomas. To determine whether P210bcr/abl can induce chronic myelogenous leukemia, murine bone marrow was infected with a retrovirus encoding P210bcr/abl and transplanted into irradiated syngeneic recipients. Transplant recipients developed several hematologic malignancies; prominent among them was a myeloproliferative syndrome closely resembling the chronic phase of human chronic myelogenous leukemia. Tumor tissue from diseased mice harbored the provirus encoding P210bcr/abl. These results demonstrate that P210bcr/abl expression can induce chronic myelogenous leukemia. Retrovirus-mediated expression of the protein provides a murine model system for further analysis of the disease." @default.
• W2076372887 created "2016-06-24" @default.
• W2076372887 creator A5004580072 @default.
• W2076372887 creator A5042763205 @default.
• W2076372887 creator A5050771079 @default.
• W2076372887 date "1990-02-16" @default.
• W2076372887 modified "2023-10-18" @default.
• W2076372887 title "Induction of Chronic Myelogenous Leukemia in Mice by the P210^{<i>bcr/abl</i>}Gene of the Philadelphia Chromosome" @default.
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• W2076372887 doi "https://doi.org/10.1126/science.2406902" @default.
• W2076372887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2406902" @default.
• W2076372887 hasPublicationYear "1990" @default.
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