FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076373695> ?p ?o ?g. }

• W2076373695 endingPage "1463" @default.
• W2076373695 startingPage "1455" @default.
• W2076373695 abstract "A phylogenetic analysis of protein disulfide isomerase (PDI) domain evolution was performed with the inclusion of recently reported PDIs from the amitochondriate protist Giardia lamblia, yeast PDIs that contain a single thioredoxin-like domain, and PDIs from a diverse selection of protists. We additionally report and include two new giardial PDIs, each with a single thioredoxin-like domain. Inclusion of protist PDIs in our analyses revealed that the evolutionary history of the endoplasmic reticulum may not be simple. Phylogenetic analyses support common ancestry of all eukaryotic PDIs from a thioredoxin ancestor and independent duplications of thioredoxin-like domains within PDIs throughout eukaryote evolution. This was particularly evident for Acanthamoeba PDI, Dictyostelium PDI, and mammalian erp5 domains. In contrast, gene duplication, instead of domain duplication, produces PDI diversity in G. lamblia. Based on our results and the known diversity of PDIs, we present a new hypothesis that the five single-domain PDIs of G. lamblia may reflect an ancestral mechanism of protein folding in the eukaryotic endoplasmic reticulum. The PDI complement of G. lamblia and yeast suggests that a combination of PDIs may be used as a redox chain analogous to that known for bacterial Dsb proteins." @default.
• W2076373695 created "2016-06-24" @default.
• W2076373695 creator A5009575004 @default.
• W2076373695 creator A5012803072 @default.
• W2076373695 creator A5027714443 @default.
• W2076373695 creator A5029144285 @default.
• W2076373695 creator A5038821210 @default.
• W2076373695 creator A5075346610 @default.
• W2076373695 date "2001-08-01" @default.
• W2076373695 modified "2023-09-25" @default.
• W2076373695 title "The Evolutionary Origins of Eukaryotic Protein Disulfide Isomerase Domains: New Evidence from the Amitochondriate Protist Giardia lamblia" @default.
• W2076373695 cites W1597865698 @default.
• W2076373695 cites W1599031232 @default.
• W2076373695 cites W1943240551 @default.
• W2076373695 cites W1965580313 @default.
• W2076373695 cites W1969864109 @default.
• W2076373695 cites W1970976951 @default.
• W2076373695 cites W1976435861 @default.
• W2076373695 cites W1982846789 @default.
• W2076373695 cites W1990154898 @default.
• W2076373695 cites W1992712435 @default.
• W2076373695 cites W1996017499 @default.
• W2076373695 cites W1996858543 @default.
• W2076373695 cites W2005145242 @default.
• W2076373695 cites W2013827094 @default.
• W2076373695 cites W2017052392 @default.
• W2076373695 cites W2017519756 @default.
• W2076373695 cites W2018419884 @default.
• W2076373695 cites W2018632843 @default.
• W2076373695 cites W2020011224 @default.
• W2076373695 cites W2020452433 @default.
• W2076373695 cites W2029511764 @default.
• W2076373695 cites W2030495727 @default.
• W2076373695 cites W2033876617 @default.
• W2076373695 cites W2034733986 @default.
• W2076373695 cites W2041671226 @default.
• W2076373695 cites W2043549786 @default.
• W2076373695 cites W2053168795 @default.
• W2076373695 cites W2057134717 @default.
• W2076373695 cites W2064508862 @default.
• W2076373695 cites W2064911759 @default.
• W2076373695 cites W2092995520 @default.
• W2076373695 cites W2100018338 @default.
• W2076373695 cites W2100893308 @default.
• W2076373695 cites W2106882534 @default.
• W2076373695 cites W2116709453 @default.
• W2076373695 cites W2131266074 @default.
• W2076373695 cites W2138755616 @default.
• W2076373695 cites W2142388402 @default.
• W2076373695 cites W2158714788 @default.
• W2076373695 cites W2159718078 @default.
• W2076373695 cites W2161243122 @default.
• W2076373695 cites W2164997158 @default.
• W2076373695 cites W2170991287 @default.
• W2076373695 cites W2171091522 @default.
• W2076373695 cites W2185936454 @default.
• W2076373695 cites W4247441571 @default.
• W2076373695 doi "https://doi.org/10.1093/oxfordjournals.molbev.a003931" @default.
• W2076373695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11470836" @default.
• W2076373695 hasPublicationYear "2001" @default.
• W2076373695 type Work @default.
• W2076373695 sameAs 2076373695 @default.
• W2076373695 citedByCount "50" @default.
• W2076373695 countsByYear W20763736952012 @default.
• W2076373695 countsByYear W20763736952013 @default.
• W2076373695 countsByYear W20763736952015 @default.
• W2076373695 countsByYear W20763736952016 @default.
• W2076373695 countsByYear W20763736952017 @default.
• W2076373695 countsByYear W20763736952018 @default.
• W2076373695 countsByYear W20763736952021 @default.
• W2076373695 countsByYear W20763736952023 @default.
• W2076373695 crossrefType "journal-article" @default.
• W2076373695 hasAuthorship W2076373695A5009575004 @default.
• W2076373695 hasAuthorship W2076373695A5012803072 @default.
• W2076373695 hasAuthorship W2076373695A5027714443 @default.
• W2076373695 hasAuthorship W2076373695A5029144285 @default.
• W2076373695 hasAuthorship W2076373695A5038821210 @default.
• W2076373695 hasAuthorship W2076373695A5075346610 @default.
• W2076373695 hasBestOaLocation W20763736951 @default.
• W2076373695 hasConcept C104317684 @default.
• W2076373695 hasConcept C144292202 @default.
• W2076373695 hasConcept C158617107 @default.
• W2076373695 hasConcept C2778330419 @default.
• W2076373695 hasConcept C2780626423 @default.
• W2076373695 hasConcept C3623737 @default.
• W2076373695 hasConcept C5098756 @default.
• W2076373695 hasConcept C54355233 @default.
• W2076373695 hasConcept C86803240 @default.
• W2076373695 hasConcept C90132467 @default.
• W2076373695 hasConcept C95444343 @default.
• W2076373695 hasConceptScore W2076373695C104317684 @default.
• W2076373695 hasConceptScore W2076373695C144292202 @default.
• W2076373695 hasConceptScore W2076373695C158617107 @default.
• W2076373695 hasConceptScore W2076373695C2778330419 @default.
• W2076373695 hasConceptScore W2076373695C2780626423 @default.
• W2076373695 hasConceptScore W2076373695C3623737 @default.
• W2076373695 hasConceptScore W2076373695C5098756 @default.
• W2076373695 hasConceptScore W2076373695C54355233 @default.

• next