FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076376185> ?p ?o ?g. }

• W2076376185 endingPage "629" @default.
• W2076376185 startingPage "623" @default.
• W2076376185 abstract "The present study evaluated the role of activin A, insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 3 (IGFBP-3) in Egyptian patients suffering from combined hepatitis C virus (HCV) infection and hepatic schistosomiasis. Four groups were included in the present study. Group I: 30 healthy subjects were included as controls; Group II (HCV): 30 patients with chronic liver disease due to HCV infection without evidence of schistosomiasis; Group III (SHF + HCV): 30 patients with combined disease, chronic schistosomal hepatic fibrosis (SHF) and chronic hepatitis C infection; Group IV (HCC): 30 patients with hepatocellular carcinoma associated with chronic hepatitis C virus and schistosomal infection. Patients with HCV, HCV + SHF and those with HCC had a significantly higher serum activin A compared with the control group (P < 0.001). Serum activin A level (mean ± SD) was 5.7 ± 2.76, 10.59 ± 3.59, 15.39 ± 4.61 and 19.93 ± 5.43 ng/mL in controls, HCV patients, HCV + SHF patients and HCC patients, respectively. Serum IGF-1 was significantly lower in HCV patients, HCV + SHF patients and HCC patients compared to the control group (P < 0.001). Serum IGF-1 was 121.7 ± 73.4, 76.7 ± 23.5, 35.7 ± 17.6 and 39.9 ± 25.9 ng/mL in controls, HCV patients, HCV + SHF patients and HCC patients, respectively. Similarly, serum IGFBP-3 was significantly lower in HCV patients, HCV + SHF patients and HCC patients compared to the control group (P < 0.001). Furthermore, serum insulin-like growth factor binding protein 3 (IGFBP-3) was significantly lower in patients with HCC compared to patients with HCV or those with HCV + SHF (P < 0.01 and P = 0.024, respectively). The median (range) of serum IGFBP-3 was 4452 (352.2–8965), 3457 (1114–6000), 2114 (867–5901) and 1202 (576–3994) ng/mL in controls, HCV patients, HCV + SHF patients and HCC patients, respectively. Serum activin A correlated positively with Child-Pugh scoring in patients with HCV, HCV + SHF and those with HCC. The correlation coefficient was significant, at 0.001, in total cases. We conclude that patients with HCV, HCV + SHF and those with HCC have a significantly higher serum activin A when compared with controls. Serum activin A level was significantly higher in patients with HCV + SHF compared to those with HCV alone (P < 0.01) with a significant positive correlation between the serum activin A level and Child-Pugh scoring in patients with HCV, HCV + SHF and those with HCC. Furthermore, serum IGF-1 and IGFBP-3 levels were significantly reduced in patients with HCV, HCV + SHF and those with HCC compared to the control group. We suggest that this pattern (high activin A and low IGF-1 and its binding protein 3) may play a role in development of HCC in Egyptian patients suffering from combined hepatitis C virus infection and hepatic schistosomiasis." @default.
• W2076376185 created "2016-06-24" @default.
• W2076376185 creator A5004367460 @default.
• W2076376185 creator A5028101187 @default.
• W2076376185 creator A5030585570 @default.
• W2076376185 creator A5036345765 @default.
• W2076376185 creator A5059470100 @default.
• W2076376185 date "2006-06-01" @default.
• W2076376185 modified "2023-10-11" @default.
• W2076376185 title "Possible contribution of serum activin A and IGF-1 in the development of hepatocellular carcinoma in Egyptian patients suffering from combined hepatitis C virus infection and hepatic schistosomiasis" @default.
• W2076376185 cites W12293267 @default.
• W2076376185 cites W144679933 @default.
• W2076376185 cites W146133000 @default.
• W2076376185 cites W1499129561 @default.
• W2076376185 cites W1839178227 @default.
• W2076376185 cites W1971023795 @default.
• W2076376185 cites W1977673261 @default.
• W2076376185 cites W1982989163 @default.
• W2076376185 cites W1986365307 @default.
• W2076376185 cites W1991456342 @default.
• W2076376185 cites W1992401642 @default.
• W2076376185 cites W1998374567 @default.
• W2076376185 cites W2011105822 @default.
• W2076376185 cites W2019801096 @default.
• W2076376185 cites W2022926813 @default.
• W2076376185 cites W2043593592 @default.
• W2076376185 cites W2045365545 @default.
• W2076376185 cites W2047335815 @default.
• W2076376185 cites W2052009555 @default.
• W2076376185 cites W2056707440 @default.
• W2076376185 cites W2059373933 @default.
• W2076376185 cites W2065960044 @default.
• W2076376185 cites W2086286077 @default.
• W2076376185 cites W2090965524 @default.
• W2076376185 cites W2097154687 @default.
• W2076376185 cites W2099228825 @default.
• W2076376185 cites W2108091943 @default.
• W2076376185 cites W2108104357 @default.
• W2076376185 cites W2115673540 @default.
• W2076376185 cites W2123720885 @default.
• W2076376185 cites W2130284279 @default.
• W2076376185 cites W2154564110 @default.
• W2076376185 cites W2171891434 @default.
• W2076376185 cites W2326843102 @default.
• W2076376185 cites W2332375831 @default.
• W2076376185 cites W4211135389 @default.
• W2076376185 cites W4212985336 @default.
• W2076376185 cites W4235908535 @default.
• W2076376185 cites W4243603686 @default.
• W2076376185 cites W4248726600 @default.
• W2076376185 cites W79846600 @default.
• W2076376185 doi "https://doi.org/10.1016/j.clinbiochem.2006.01.022" @default.
• W2076376185 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16624274" @default.
• W2076376185 hasPublicationYear "2006" @default.
• W2076376185 type Work @default.
• W2076376185 sameAs 2076376185 @default.
• W2076376185 citedByCount "31" @default.
• W2076376185 countsByYear W20763761852012 @default.
• W2076376185 countsByYear W20763761852013 @default.
• W2076376185 countsByYear W20763761852014 @default.
• W2076376185 countsByYear W20763761852015 @default.
• W2076376185 countsByYear W20763761852016 @default.
• W2076376185 countsByYear W20763761852018 @default.
• W2076376185 countsByYear W20763761852021 @default.
• W2076376185 countsByYear W20763761852023 @default.
• W2076376185 crossrefType "journal-article" @default.
• W2076376185 hasAuthorship W2076376185A5004367460 @default.
• W2076376185 hasAuthorship W2076376185A5028101187 @default.
• W2076376185 hasAuthorship W2076376185A5030585570 @default.
• W2076376185 hasAuthorship W2076376185A5036345765 @default.
• W2076376185 hasAuthorship W2076376185A5059470100 @default.
• W2076376185 hasConcept C126322002 @default.
• W2076376185 hasConcept C165901193 @default.
• W2076376185 hasConcept C203014093 @default.
• W2076376185 hasConcept C2522874641 @default.
• W2076376185 hasConcept C2776225656 @default.
• W2076376185 hasConcept C2776408679 @default.
• W2076376185 hasConcept C2776455275 @default.
• W2076376185 hasConcept C2777075537 @default.
• W2076376185 hasConcept C2778019345 @default.
• W2076376185 hasConcept C2780559512 @default.
• W2076376185 hasConcept C2993667909 @default.
• W2076376185 hasConcept C71924100 @default.
• W2076376185 hasConcept C90924648 @default.
• W2076376185 hasConceptScore W2076376185C126322002 @default.
• W2076376185 hasConceptScore W2076376185C165901193 @default.
• W2076376185 hasConceptScore W2076376185C203014093 @default.
• W2076376185 hasConceptScore W2076376185C2522874641 @default.
• W2076376185 hasConceptScore W2076376185C2776225656 @default.
• W2076376185 hasConceptScore W2076376185C2776408679 @default.
• W2076376185 hasConceptScore W2076376185C2776455275 @default.
• W2076376185 hasConceptScore W2076376185C2777075537 @default.
• W2076376185 hasConceptScore W2076376185C2778019345 @default.
• W2076376185 hasConceptScore W2076376185C2780559512 @default.
• W2076376185 hasConceptScore W2076376185C2993667909 @default.
• W2076376185 hasConceptScore W2076376185C71924100 @default.
• W2076376185 hasConceptScore W2076376185C90924648 @default.
• W2076376185 hasIssue "6" @default.

• next