FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076377118> ?p ?o ?g. }

• W2076377118 endingPage "458" @default.
• W2076377118 startingPage "449" @default.
• W2076377118 abstract "Abstract BACKGROUND Folic acid is essential for the synthesis of nucleotides and methyl transfer reactions. Folic acid–binding protein one (Folbp1) is the primary mediator of folic acid transport into murine cells. Folbp1 knockout mouse embryos die in utero with multiple malformations, including severe congenital heart defects (CHDs). Although maternal folate supplementation is believed to prevent human conotruncal heart defects, its precise role during cardiac morphogenesis remains unclear. In this study, we examined the role of folic acid on the phenotypic expression of heart defects in Folbp1 mice, mindful of the importance of neural crest cells to the formation of the conotruncus. METHODS To determine if the Folbp1 gene participates in the commitment and differentiation of the cardiomyocytes, relative levels of dead and proliferating precursor cells in the heart were examined by flow cytometry, Western blot, and immunohistostaining. RESULTS Our studies revealed that impaired folic acid transport results in extensive apoptosis‐mediated cell death, which concentrated in the interventricular septum and truncus arteriosus, thus being anatomically restricted to the two regions of congenital heart defects. Together with a reduced proliferative capacity of the cardiomyocytes, the limited size of the available precursor cell pool may contribute to the observed cardiac defects. Notably, there is a substantial reduction in Pax‐3 expression in the region of the presumptive migrating cardiac neural crest, suggesting that this cell population may be the most severely affected by the massive cell death. CONCLUSIONS Our findings demonstrate for the first time a prominent role of the Folbp1 gene in mediating susceptibility to heart defects. Birth Defects Research (Part A), 2004. © 2004 Wiley‐Liss, Inc." @default.
• W2076377118 created "2016-06-24" @default.
• W2076377118 creator A5058320831 @default.
• W2076377118 creator A5073998216 @default.
• W2076377118 creator A5075319792 @default.
• W2076377118 creator A5086475636 @default.
• W2076377118 creator A5087807911 @default.
• W2076377118 date "2004-06-25" @default.
• W2076377118 modified "2023-10-12" @default.
• W2076377118 title "Developmental consequences of abnormal folate transport during murine heart morphogenesis" @default.
• W2076377118 cites W110925524 @default.
• W2076377118 cites W1481448793 @default.
• W2076377118 cites W1597619535 @default.
• W2076377118 cites W1760771044 @default.
• W2076377118 cites W1927233045 @default.
• W2076377118 cites W1927984605 @default.
• W2076377118 cites W1948282121 @default.
• W2076377118 cites W1965236691 @default.
• W2076377118 cites W1973359452 @default.
• W2076377118 cites W1973511812 @default.
• W2076377118 cites W1973972027 @default.
• W2076377118 cites W1975357252 @default.
• W2076377118 cites W1977926834 @default.
• W2076377118 cites W1982481882 @default.
• W2076377118 cites W1995877613 @default.
• W2076377118 cites W1999087237 @default.
• W2076377118 cites W2004561527 @default.
• W2076377118 cites W2015003077 @default.
• W2076377118 cites W2020559241 @default.
• W2076377118 cites W2022507419 @default.
• W2076377118 cites W2027007621 @default.
• W2076377118 cites W2027308884 @default.
• W2076377118 cites W2037447292 @default.
• W2076377118 cites W2045668564 @default.
• W2076377118 cites W2045702252 @default.
• W2076377118 cites W2056794607 @default.
• W2076377118 cites W2057164201 @default.
• W2076377118 cites W2068653999 @default.
• W2076377118 cites W2070236076 @default.
• W2076377118 cites W2078393889 @default.
• W2076377118 cites W2081555166 @default.
• W2076377118 cites W2085185799 @default.
• W2076377118 cites W2096375496 @default.
• W2076377118 cites W2097392023 @default.
• W2076377118 cites W2115833670 @default.
• W2076377118 cites W2116403328 @default.
• W2076377118 cites W2126732550 @default.
• W2076377118 cites W2127429864 @default.
• W2076377118 cites W2128694891 @default.
• W2076377118 cites W2148454249 @default.
• W2076377118 cites W2315337958 @default.
• W2076377118 cites W32741228 @default.
• W2076377118 doi "https://doi.org/10.1002/bdra.20043" @default.
• W2076377118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15259034" @default.
• W2076377118 hasPublicationYear "2004" @default.
• W2076377118 type Work @default.
• W2076377118 sameAs 2076377118 @default.
• W2076377118 citedByCount "64" @default.
• W2076377118 countsByYear W20763771182012 @default.
• W2076377118 countsByYear W20763771182013 @default.
• W2076377118 countsByYear W20763771182014 @default.
• W2076377118 countsByYear W20763771182015 @default.
• W2076377118 countsByYear W20763771182016 @default.
• W2076377118 countsByYear W20763771182018 @default.
• W2076377118 countsByYear W20763771182019 @default.
• W2076377118 countsByYear W20763771182021 @default.
• W2076377118 countsByYear W20763771182022 @default.
• W2076377118 crossrefType "journal-article" @default.
• W2076377118 hasAuthorship W2076377118A5058320831 @default.
• W2076377118 hasAuthorship W2076377118A5073998216 @default.
• W2076377118 hasAuthorship W2076377118A5075319792 @default.
• W2076377118 hasAuthorship W2076377118A5086475636 @default.
• W2076377118 hasAuthorship W2076377118A5087807911 @default.
• W2076377118 hasConcept C104317684 @default.
• W2076377118 hasConcept C126322002 @default.
• W2076377118 hasConcept C126749454 @default.
• W2076377118 hasConcept C134018914 @default.
• W2076377118 hasConcept C145103041 @default.
• W2076377118 hasConcept C196843134 @default.
• W2076377118 hasConcept C2908647359 @default.
• W2076377118 hasConcept C40692019 @default.
• W2076377118 hasConcept C54355233 @default.
• W2076377118 hasConcept C62425271 @default.
• W2076377118 hasConcept C71924100 @default.
• W2076377118 hasConcept C86803240 @default.
• W2076377118 hasConcept C95444343 @default.
• W2076377118 hasConcept C99454951 @default.
• W2076377118 hasConceptScore W2076377118C104317684 @default.
• W2076377118 hasConceptScore W2076377118C126322002 @default.
• W2076377118 hasConceptScore W2076377118C126749454 @default.
• W2076377118 hasConceptScore W2076377118C134018914 @default.
• W2076377118 hasConceptScore W2076377118C145103041 @default.
• W2076377118 hasConceptScore W2076377118C196843134 @default.
• W2076377118 hasConceptScore W2076377118C2908647359 @default.
• W2076377118 hasConceptScore W2076377118C40692019 @default.
• W2076377118 hasConceptScore W2076377118C54355233 @default.
• W2076377118 hasConceptScore W2076377118C62425271 @default.
• W2076377118 hasConceptScore W2076377118C71924100 @default.

• next