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- W2076377564 abstract "Summary: Intracellular calcium plays an essential role in regulation of many cellular processes, but increases in internal calcium levels can also exacerbate pathophysiologic or pharmacologic responses, in particular myocardial arrhythmias. Pharmacologic increases in intracellular calcium may be obtained by opening calcium channels, either directly or indirectly, or by increasing calcium release from intracellular stores. In this study, cesium chloride administered intracoronarily (i.c.) through the left anterior descending coronary artery (LAD) dosedependently elicited ventricular arrhythmias. Glyburide (3 μg/kg/min i.c.), clofilium (1 μg/kg/min i.c.), or ryanodine (0.03 μg/kg/min i.c.) exacerbated arrhythmias. Specifically, the ED50 values for cesium were shifted from 0.56 mM in the vehicle group to 0.17, 0.27, and 0.20 mM in the glyburide, clofilium, and ryanodine groups, respectively. Coronary blood flow (CBF) and blood pressure (BP) did not change significantly in any treatment group. Effects of glyburide were not mediated by either insulin or decreased glucose levels, since infusions of insulin (decreasing blood glucose to 20 mg/dl) did not exacerbate arrhythmias. In vitro electrophysiologic studies showed that glyburide (1 μM) and ryanodine (1 μM) did not significantly affect action potential durations (APD). In contrast, clofilium (1 μM) significantly prolonged APD. These results demonstrate that glyburide, clofilium, and ryanodine tend to exacerbate cesium-induced arrhythmias. We suggest that glyburide and ryanodine may exacerbate arrhythmias by increasing internal calcium from intracellular stores, whereas clofilium may increase internal calcium by increasing influx of calcium across the sarcolemma." @default.
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- W2076377564 date "1994-03-01" @default.
- W2076377564 modified "2023-10-18" @default.
- W2076377564 title "Effects of Intracoronary Glyburide on Cesium-Induced Arrhythmias in Anesthetized Dogs" @default.
- W2076377564 doi "https://doi.org/10.1097/00005344-199403000-00013" @default.
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