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• W2076377941 startingPage "454" @default.
• W2076377941 abstract "Phosphatidylinositol lipid signaling cascades are integral part of TCR-CD3 signaling. The mechanisms by which phosphatidylinositol kinases are coupled to TCR-CD3 complex remain elusive. Here we report an association of type II PtdIns 4-kinase with TCR-CD3 zeta chain upon cross-linking. Mapping studies have revealed that the C-terminal ITAM is critical for docking of the enzyme on the zeta chain. The association is shown to be tyrosyl phosphorylation dependent as mutation of Y-151 and Y-142 on the C-terminal ITAM disrupts interaction of the two proteins. Identification of the associated type II PtdIns 4-kinase revealed that the beta isoform of the enzyme interacts with the zeta chain in vivo." @default.
• W2076377941 created "2016-06-24" @default.
• W2076377941 creator A5030158492 @default.
• W2076377941 creator A5073678879 @default.
• W2076377941 creator A5084011827 @default.
• W2076377941 date "2006-02-01" @default.
• W2076377941 modified "2023-10-11" @default.
• W2076377941 title "Type II phosphatidylinositol 4-kinase β associates with TCR-CD3 ζ chain in Jurkat cells" @default.
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• W2076377941 doi "https://doi.org/10.1016/j.molimm.2005.03.009" @default.
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• W2076377941 hasPublicationYear "2006" @default.
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