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• W2076379343 abstract "Abstract: Botulinum C2 toxin is known to ADP‐ribosylate actin. The toxin effect was studied on [ 3 H]noradrenaline secretion of PC12 cells. [ 3 H]Noradrenaline release was stimulated five‐ to 15‐fold by carbachol (100 μ M ) or K + (50 m M ) and 10–30‐fold by the ionophore A23187 (5 μ M ). Pretreatment of PC12 cells with botulinum C2 toxin for 4–8 h at 20°C, increased carbachol‐, K + ‐, and A23187‐induced, but not basal, [ 3 H]noradrenaline release maximally 1.5‐ to threefold, whereas ≥75% of the cellular actin pool was ADP‐ribosylated. Treatment of PC12 cells with botulinum C2 toxin for up to 1 h at 37°C also increased stimulated [ 3 H]noradrenaline secretion, whereas toxin treatment for > 1 h decreased the enhanced [ 3 H]noradrenaline release stimulated by carbachol and K + but not by A23187. Concomitantly with toxin‐induced stimulation of secretion, 20–50% of the cellular actin was ADP‐ribosylated, whereas >60% of actin was modified when exocytosis was attenuated. The data indicate that ADP‐ribosylation of actin by botulinum C2 toxin largely modulates stimulation of [ 3 H]noradrenaline release. Moreover, the biphasic toxin effects suggest that distinct mechanisms are involved in the role of actin in secretion." @default.
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• W2076379343 date "1989-02-01" @default.
• W2076379343 modified "2023-09-29" @default.
• W2076379343 title "Actin Involvement in Exocytosis from PC12 Cells: Studies on the Influence of Botulinum C2 Toxin on Stimulated Noradrenaline Release" @default.
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• W2076379343 doi "https://doi.org/10.1111/j.1471-4159.1989.tb09131.x" @default.
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