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- W2076382687 abstract "Subtotal (95%) pancreatectomy has been advocated for hyperinsulinemic hypoglycemia unresponsive to medical therapy. We studied pancreatic exocrine function in infants with ICD before surgery, 1-2 mths after 95% resection of the pancreas (early po), and 1-2 yrs later (late po). We used a quantitative perfusion technique to collect duodenal secretions during pancreatic stimulation with IV secretin and CCK. Results are expressed as mean units/kg/hr, mean mEq/kg/hr(HCO3) and % of mean age-matched control values. Pre-op mean trypsin and HCO3 secretion was depressed in ICD during medical therapy. Despite 95% resection, all pts had sufficient pancreatic function to absorb fat normally. By 2 mths po, considerable residual secretory capacity was present. Further functional improvement had occurred 1-2 yrs later. One pt operated on for recurrent hypoglycemia had definite evidence of pancreatic regeneration 3 yrs after initial resection. These pts demonstrate that infants may have significant potential to increase pancreatic exocrine secretory capacity after major resection, independent of developmental changes, presumably due to regenerative hyperplasia and/or hypertrophy." @default.
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- W2076382687 date "1984-04-01" @default.
- W2076382687 modified "2023-09-27" @default.
- W2076382687 title "PANCREATIC EXOCRINE FUNCTION IN ISLET CELL DYSPLASIA (ICD)AFTER 95% RESECTION" @default.
- W2076382687 doi "https://doi.org/10.1203/00006450-198404001-00659" @default.
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