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- W2076384911 abstract "In this study, we investigated the correlation between the production by Pseudomonas aeruginosa isolates of four exoenzymes (protease, elastase, neuraminidase, and phospholipase C (PLC)) and the clinical state of cystic fibrosis (CF) patients. We studied 212 P. aeruginosa isolates from 22 CF patients chronically infected with this bacterium. Patients were classified into three clinical groups according to a modified Shwachman-Kulczycki-Khaw (SKK) scoring system. The production of enzymes by isolates from patients in the three populations was analyzed and compared using four statistical tests: chi-square, Mann-Whitney U, principal component analysis, and discriminant analysis. Isolates from patients with excellent or good clinical status (group I, SKK score >/=71) had higher elastase and neuraminidase activities than isolates from the other patients. In contrast, PLC activity, a common characteristic of CF isolates, was higher in isolates from patients with poor or weak clinical status (group III, SKK score </=55). PLC also appeared to be the best parameter for differentiating between groups I and III. Enzyme production was highly variable in group II isolates (SKK score, 56-70). Our results suggest that P. aeruginosa isolates from patients with good clinical status produce large amounts of neuraminidase, and that PLC production may be involved in the decrease in pulmonary function." @default.
- W2076384911 created "2016-06-24" @default.
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- W2076384911 date "2003-09-25" @default.
- W2076384911 modified "2023-10-18" @default.
- W2076384911 title "Pseudomonas aeruginosa and cystic fibrosis: Correlation between exoenzyme production and patient's clinical state" @default.
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- W2076384911 doi "https://doi.org/10.1002/ppul.10380" @default.
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