FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076386504> ?p ?o ?g. }

• W2076386504 endingPage "982" @default.
• W2076386504 startingPage "975" @default.
• W2076386504 abstract "N(4)-Behenoyl-1-beta-D-arabinofuranosylcytosine (BHAC), a prodrug of 1-beta-D-arabinofuranosylcytosine, is used effectively for the treatment of leukemia in Japan. BHAC therapy may be more effective if it is delivered in conjunction with monitoring of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate (ara-CTP), the intracellular active metabolite of ara-C derived from BHAC. However, previous monitoring methods for ara-CTP were insufficiently sensitive. Here, using our new sensitive method, we evaluated the ara-CTP pharmacokinetics in relation to the therapeutic response in 11 acute myelogenous leukemia patients who received a 2-h infusion of BHAC (70 mg / m(2)) in combination remission induction therapy. ara-CTP could be monitored at levels under 1 mM. BHAC maintained effective levels of plasma ara-C and intracellular ara-CTP for a longer time, even compared with historical values of high-dose ara-C. The area under the concentration-time curve of ara-CTP was significantly greater in the patients with complete remission than in the patients without response. This greater amount of ara-CTP was attributed to the higher ara-CTP concentrations achieved in the responding patients. There was no apparent difference of plasma ara-C pharmacokinetics between the two groups. Thus, for the first time, the ara-CTP pharmacokinetics was evaluated in relation to the therapeutic effect of BHAC, and the importance of ara-CTP was proven. Administration of optimal BHAC therapy may require monitoring of the ara-CTP pharmacokinetics in each individual patient." @default.
• W2076386504 created "2016-06-24" @default.
• W2076386504 creator A5011340584 @default.
• W2076386504 creator A5013873963 @default.
• W2076386504 creator A5020680556 @default.
• W2076386504 creator A5022142826 @default.
• W2076386504 creator A5035780359 @default.
• W2076386504 creator A5042047703 @default.
• W2076386504 creator A5054279320 @default.
• W2076386504 creator A5054372643 @default.
• W2076386504 creator A5077635586 @default.
• W2076386504 creator A5080736574 @default.
• W2076386504 creator A5080877633 @default.
• W2076386504 creator A5080945589 @default.
• W2076386504 date "2001-09-01" @default.
• W2076386504 modified "2023-10-16" @default.
• W2076386504 title "Close Correlation of 1-β-D-Arabinofuranosylcytosine 5′-Triphosphate, an Intracellular Active Metabolite, to the Therapeutic Efficacy of<i>N</i>⁴-Behenoyl-1-β-D-arabinofuranosylcytosine Therapy for Acute Myelogenous Leukemia" @default.
• W2076386504 cites W13703435 @default.
• W2076386504 cites W1484115889 @default.
• W2076386504 cites W1491166067 @default.
• W2076386504 cites W1538590228 @default.
• W2076386504 cites W1559200685 @default.
• W2076386504 cites W1560442194 @default.
• W2076386504 cites W1575253299 @default.
• W2076386504 cites W1764679967 @default.
• W2076386504 cites W1808968650 @default.
• W2076386504 cites W1873190455 @default.
• W2076386504 cites W1937894144 @default.
• W2076386504 cites W1969312196 @default.
• W2076386504 cites W1990899997 @default.
• W2076386504 cites W1994229131 @default.
• W2076386504 cites W2007557971 @default.
• W2076386504 cites W2024927225 @default.
• W2076386504 cites W2041557965 @default.
• W2076386504 cites W2047357233 @default.
• W2076386504 cites W2051669578 @default.
• W2076386504 cites W2059545303 @default.
• W2076386504 cites W2110008506 @default.
• W2076386504 cites W2118816811 @default.
• W2076386504 cites W2128036895 @default.
• W2076386504 cites W2143630004 @default.
• W2076386504 cites W2146197778 @default.
• W2076386504 cites W2160850143 @default.
• W2076386504 cites W2217001796 @default.
• W2076386504 cites W2266555757 @default.
• W2076386504 cites W2341116212 @default.
• W2076386504 cites W2405615623 @default.
• W2076386504 cites W2410122496 @default.
• W2076386504 cites W2414865654 @default.
• W2076386504 cites W2416449692 @default.
• W2076386504 cites W2462779651 @default.
• W2076386504 cites W2463518567 @default.
• W2076386504 cites W2465762584 @default.
• W2076386504 cites W1651358555 @default.
• W2076386504 cites W2416090825 @default.
• W2076386504 doi "https://doi.org/10.1111/j.1349-7006.2001.tb01188.x" @default.
• W2076386504 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5926845" @default.
• W2076386504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11572766" @default.
• W2076386504 hasPublicationYear "2001" @default.
• W2076386504 type Work @default.
• W2076386504 sameAs 2076386504 @default.
• W2076386504 citedByCount "8" @default.
• W2076386504 countsByYear W20763865042013 @default.
• W2076386504 countsByYear W20763865042017 @default.
• W2076386504 countsByYear W20763865042022 @default.
• W2076386504 crossrefType "journal-article" @default.
• W2076386504 hasAuthorship W2076386504A5011340584 @default.
• W2076386504 hasAuthorship W2076386504A5013873963 @default.
• W2076386504 hasAuthorship W2076386504A5020680556 @default.
• W2076386504 hasAuthorship W2076386504A5022142826 @default.
• W2076386504 hasAuthorship W2076386504A5035780359 @default.
• W2076386504 hasAuthorship W2076386504A5042047703 @default.
• W2076386504 hasAuthorship W2076386504A5054279320 @default.
• W2076386504 hasAuthorship W2076386504A5054372643 @default.
• W2076386504 hasAuthorship W2076386504A5077635586 @default.
• W2076386504 hasAuthorship W2076386504A5080736574 @default.
• W2076386504 hasAuthorship W2076386504A5080877633 @default.
• W2076386504 hasAuthorship W2076386504A5080945589 @default.
• W2076386504 hasBestOaLocation W20763865041 @default.
• W2076386504 hasConcept C102652120 @default.
• W2076386504 hasConcept C112705442 @default.
• W2076386504 hasConcept C126322002 @default.
• W2076386504 hasConcept C2776694085 @default.
• W2076386504 hasConcept C2777477808 @default.
• W2076386504 hasConcept C2778041864 @default.
• W2076386504 hasConcept C2778397455 @default.
• W2076386504 hasConcept C2778461978 @default.
• W2076386504 hasConcept C71924100 @default.
• W2076386504 hasConcept C90924648 @default.
• W2076386504 hasConcept C98274493 @default.
• W2076386504 hasConceptScore W2076386504C102652120 @default.
• W2076386504 hasConceptScore W2076386504C112705442 @default.
• W2076386504 hasConceptScore W2076386504C126322002 @default.
• W2076386504 hasConceptScore W2076386504C2776694085 @default.
• W2076386504 hasConceptScore W2076386504C2777477808 @default.
• W2076386504 hasConceptScore W2076386504C2778041864 @default.
• W2076386504 hasConceptScore W2076386504C2778397455 @default.
• W2076386504 hasConceptScore W2076386504C2778461978 @default.

• next