Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076392120> ?p ?o ?g. }
- W2076392120 endingPage "1348" @default.
- W2076392120 startingPage "1339" @default.
- W2076392120 abstract "Cultured cortical neurons exposed for 24 h to low concentrations of the Ca2+ ionophores, ionomycin (250 nM) or A-23187 (100 nM), underwent apoptosis, accompanied by early degeneration of neurites, cell body shrinkage, chromatin condensation and internucleosomal DNA fragmentation. This death could be blocked by protein synthesis inhibitors, as well as by the growth factors brain-derived neurotrophic factor or insulin-like growth factor I. If the ionomycin concentration was increased to 1-3 microM, then neurons underwent necrosis, accompanied by early cell body swelling without DNA laddering, or sensitivity to cycloheximide or growth factors. Calcium imaging with Fura-2 suggested a possible basis for the differential effects of low and high concentrations of ionomycin. At low concentrations, ionomycin induced greater increases in intracellular Ca2+ concentration in neurites than in neuronal cell bodies, whereas at high concentrations, ionomycin produced large increases in intracellular Ca2+ concentration in both neurites and cell bodies. We hypothesize that the ability of low concentrations of Ca2+ ionophores to raise intracellular Ca2+ concentration preferentially in neurites caused early neurite degeneration, leading to loss of growth factor availability to the cell body and consequent apoptosis, whereas high concentrations of ionophores produced global cellular Ca2+ overload and consequent necrosis." @default.
- W2076392120 created "2016-06-24" @default.
- W2076392120 creator A5005050761 @default.
- W2076392120 creator A5013806425 @default.
- W2076392120 creator A5021775076 @default.
- W2076392120 creator A5037788679 @default.
- W2076392120 creator A5057653909 @default.
- W2076392120 creator A5058319971 @default.
- W2076392120 creator A5079069459 @default.
- W2076392120 creator A5081691358 @default.
- W2076392120 date "1999-06-01" @default.
- W2076392120 modified "2023-09-30" @default.
- W2076392120 title "Calcium ionophores can induce either apoptosis or necrosis in cultured cortical neurons" @default.
- W2076392120 cites W1544998723 @default.
- W2076392120 cites W1571251056 @default.
- W2076392120 cites W1609471181 @default.
- W2076392120 cites W1887017620 @default.
- W2076392120 cites W1907196977 @default.
- W2076392120 cites W1907724378 @default.
- W2076392120 cites W1910864442 @default.
- W2076392120 cites W1965119464 @default.
- W2076392120 cites W1966434770 @default.
- W2076392120 cites W1969502142 @default.
- W2076392120 cites W1972130056 @default.
- W2076392120 cites W1975896299 @default.
- W2076392120 cites W1982266219 @default.
- W2076392120 cites W1982598770 @default.
- W2076392120 cites W1983227243 @default.
- W2076392120 cites W1990285880 @default.
- W2076392120 cites W1991309822 @default.
- W2076392120 cites W1996052713 @default.
- W2076392120 cites W1996568613 @default.
- W2076392120 cites W1997611160 @default.
- W2076392120 cites W2011272696 @default.
- W2076392120 cites W2014599626 @default.
- W2076392120 cites W2016293448 @default.
- W2076392120 cites W2016575029 @default.
- W2076392120 cites W2016640140 @default.
- W2076392120 cites W2017169241 @default.
- W2076392120 cites W2017759707 @default.
- W2076392120 cites W2023462778 @default.
- W2076392120 cites W2025025522 @default.
- W2076392120 cites W2026053667 @default.
- W2076392120 cites W2028577931 @default.
- W2076392120 cites W2029479814 @default.
- W2076392120 cites W2035692772 @default.
- W2076392120 cites W2044333041 @default.
- W2076392120 cites W2044647611 @default.
- W2076392120 cites W2047082179 @default.
- W2076392120 cites W2051395367 @default.
- W2076392120 cites W2052853635 @default.
- W2076392120 cites W2053710386 @default.
- W2076392120 cites W2057135745 @default.
- W2076392120 cites W2061650382 @default.
- W2076392120 cites W2068160160 @default.
- W2076392120 cites W2069527370 @default.
- W2076392120 cites W2069855944 @default.
- W2076392120 cites W2070964315 @default.
- W2076392120 cites W2071577950 @default.
- W2076392120 cites W2076994376 @default.
- W2076392120 cites W2077744255 @default.
- W2076392120 cites W2079787007 @default.
- W2076392120 cites W2081132514 @default.
- W2076392120 cites W2082490296 @default.
- W2076392120 cites W2084609653 @default.
- W2076392120 cites W2089408469 @default.
- W2076392120 cites W2089624538 @default.
- W2076392120 cites W2091097006 @default.
- W2076392120 cites W2095111472 @default.
- W2076392120 cites W2097293665 @default.
- W2076392120 cites W2097607289 @default.
- W2076392120 cites W2101462909 @default.
- W2076392120 cites W2107100596 @default.
- W2076392120 cites W2115217673 @default.
- W2076392120 cites W2118741542 @default.
- W2076392120 cites W2141260882 @default.
- W2076392120 cites W2142836104 @default.
- W2076392120 cites W2146346171 @default.
- W2076392120 cites W2147416879 @default.
- W2076392120 cites W2172205541 @default.
- W2076392120 cites W2266365863 @default.
- W2076392120 cites W2319738071 @default.
- W2076392120 cites W2496647201 @default.
- W2076392120 cites W4253274087 @default.
- W2076392120 cites W4298115426 @default.
- W2076392120 cites W90022023 @default.
- W2076392120 doi "https://doi.org/10.1016/s0306-4522(98)00508-9" @default.
- W2076392120 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10338301" @default.
- W2076392120 hasPublicationYear "1999" @default.
- W2076392120 type Work @default.
- W2076392120 sameAs 2076392120 @default.
- W2076392120 citedByCount "112" @default.
- W2076392120 countsByYear W20763921202012 @default.
- W2076392120 countsByYear W20763921202013 @default.
- W2076392120 countsByYear W20763921202014 @default.
- W2076392120 countsByYear W20763921202015 @default.
- W2076392120 countsByYear W20763921202016 @default.
- W2076392120 countsByYear W20763921202017 @default.