Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076394484> ?p ?o ?g. }
- W2076394484 endingPage "324" @default.
- W2076394484 startingPage "314" @default.
- W2076394484 abstract "Dyslipidemia is common in patients with diabetes mellitus (DM) and is considered a risk factor for the progression of diabetic nephropathy (DN). Hyperlipidemia and hyperglycemia act synergistically to induce renal injury. The present study was designed to investigate the protective effects of tocotrienols as tocotrienol-rich fraction (TRF) extracted from palm (PO) and rice bran oils (RBO) against lipid induced nephropathy in type-2 diabetic rats and its probable molecular mechanism. Male Wistar rats (175-200 g) were divided into four groups. The first group served as diabetic control, while the second and third groups received PO-TRF and RBO-TRF, respectively by gavage over a period of sixteen weeks post-induction of diabetes. The fourth group comprised of age-matched rats that served as normal control. The effects of TRF on serum lipid profile, oxidative stress markers, expression of TGF-β, fibronectin and collagen type IV were analyzed in the kidney of diabetic rats. Treatment with PO-TRF and RBO-TRF significantly improved glycemic status, serum lipid profile and renal function in type-2 diabetic rats. In addition, TRF supplementation down-regulated the expression of TGF-β, fibronectin and collagen type IV in the kidney of diabetic rats. Transforming growth factor-β (TGF-β) plays a critical role in progression of DN, but its modulation by tocotrienols in DN remains unexplored. TRF ameliorated lipid induced nephropathy in type-2 diabetes by its hypoglycemic, hypolipidemic and antioxidant activities as well as by modulation of TGF-β to prevent increased expression of collagen type IV and fibrinogen. We finally propose a mechanism for the expression of molecular markers that are significant in the events leading to diabetic nephropathy and its modulation by tocotrienols/TRF." @default.
- W2076394484 created "2016-06-24" @default.
- W2076394484 creator A5011246605 @default.
- W2076394484 creator A5042446340 @default.
- W2076394484 creator A5072073823 @default.
- W2076394484 creator A5074570955 @default.
- W2076394484 date "2013-12-01" @default.
- W2076394484 modified "2023-10-16" @default.
- W2076394484 title "Protective effects of tocotrienols against lipid-induced nephropathy in experimental type-2 diabetic rats by modulation in TGF-β expression" @default.
- W2076394484 cites W1545899030 @default.
- W2076394484 cites W1612952173 @default.
- W2076394484 cites W1880335557 @default.
- W2076394484 cites W1964537939 @default.
- W2076394484 cites W1966215425 @default.
- W2076394484 cites W1969961684 @default.
- W2076394484 cites W1971865201 @default.
- W2076394484 cites W1974466887 @default.
- W2076394484 cites W1979232159 @default.
- W2076394484 cites W1980599464 @default.
- W2076394484 cites W1982554330 @default.
- W2076394484 cites W1983310681 @default.
- W2076394484 cites W1983442296 @default.
- W2076394484 cites W1993000626 @default.
- W2076394484 cites W1995243968 @default.
- W2076394484 cites W1996312360 @default.
- W2076394484 cites W1997735511 @default.
- W2076394484 cites W1999917583 @default.
- W2076394484 cites W2007108460 @default.
- W2076394484 cites W2009729476 @default.
- W2076394484 cites W2009785705 @default.
- W2076394484 cites W2011910330 @default.
- W2076394484 cites W2015319106 @default.
- W2076394484 cites W2016257140 @default.
- W2076394484 cites W2017010150 @default.
- W2076394484 cites W2017729853 @default.
- W2076394484 cites W2018075545 @default.
- W2076394484 cites W2023102331 @default.
- W2076394484 cites W2023304806 @default.
- W2076394484 cites W2035448725 @default.
- W2076394484 cites W2041956415 @default.
- W2076394484 cites W2044089686 @default.
- W2076394484 cites W2046382167 @default.
- W2076394484 cites W2047076693 @default.
- W2076394484 cites W2047234062 @default.
- W2076394484 cites W2047357263 @default.
- W2076394484 cites W2048723842 @default.
- W2076394484 cites W2048934315 @default.
- W2076394484 cites W2050967471 @default.
- W2076394484 cites W2051707833 @default.
- W2076394484 cites W2060274793 @default.
- W2076394484 cites W2063016600 @default.
- W2076394484 cites W2064649898 @default.
- W2076394484 cites W2068166346 @default.
- W2076394484 cites W2071124826 @default.
- W2076394484 cites W2075762798 @default.
- W2076394484 cites W2078314324 @default.
- W2076394484 cites W2080563483 @default.
- W2076394484 cites W2083245140 @default.
- W2076394484 cites W2088866343 @default.
- W2076394484 cites W2095578238 @default.
- W2076394484 cites W2101051256 @default.
- W2076394484 cites W2107376901 @default.
- W2076394484 cites W2115657282 @default.
- W2076394484 cites W2116404316 @default.
- W2076394484 cites W2117526766 @default.
- W2076394484 cites W2119696252 @default.
- W2076394484 cites W2122981222 @default.
- W2076394484 cites W2126317966 @default.
- W2076394484 cites W2134552023 @default.
- W2076394484 cites W2136305436 @default.
- W2076394484 cites W2148637873 @default.
- W2076394484 cites W2152146333 @default.
- W2076394484 cites W2155009865 @default.
- W2076394484 cites W2159518661 @default.
- W2076394484 cites W2162154857 @default.
- W2076394484 cites W2163784004 @default.
- W2076394484 cites W2164287441 @default.
- W2076394484 cites W4293247451 @default.
- W2076394484 doi "https://doi.org/10.1016/j.taap.2013.09.004" @default.
- W2076394484 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24041758" @default.
- W2076394484 hasPublicationYear "2013" @default.
- W2076394484 type Work @default.
- W2076394484 sameAs 2076394484 @default.
- W2076394484 citedByCount "49" @default.
- W2076394484 countsByYear W20763944842014 @default.
- W2076394484 countsByYear W20763944842015 @default.
- W2076394484 countsByYear W20763944842016 @default.
- W2076394484 countsByYear W20763944842017 @default.
- W2076394484 countsByYear W20763944842018 @default.
- W2076394484 countsByYear W20763944842019 @default.
- W2076394484 countsByYear W20763944842020 @default.
- W2076394484 countsByYear W20763944842021 @default.
- W2076394484 countsByYear W20763944842022 @default.
- W2076394484 crossrefType "journal-article" @default.
- W2076394484 hasAuthorship W2076394484A5011246605 @default.
- W2076394484 hasAuthorship W2076394484A5042446340 @default.
- W2076394484 hasAuthorship W2076394484A5072073823 @default.
- W2076394484 hasAuthorship W2076394484A5074570955 @default.