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• W2076398093 startingPage "1571" @default.
• W2076398093 abstract "Apoptosis of Jurkat T cells induced the caspase-mediated proteolytic cleavage of p21-activated kinase 2 (PAK2). Cleavage occurred between the amino-terminal regulatory domain and the carboxyl-terminal catalytic domain, which generated a constitutively active PAK2 fragment. Stable Jurkat cell lines that expressed a dominant-negative PAK mutant were resistant to the Fas-induced formation of apoptotic bodies, but had an enhanced externalization of phosphatidylserine at the cell surface. Thus, proteolytic activation of PAK2 represents a guanosine triphosphatase-independent mechanism of PAK regulation that allows PAK2 to regulate morphological changes that are seen in apoptotic cells." @default.
• W2076398093 created "2016-06-24" @default.
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• W2076398093 date "1997-06-06" @default.
• W2076398093 modified "2023-10-10" @default.
• W2076398093 title "Membrane and Morphological Changes in Apoptotic Cells Regulated by Caspase-Mediated Activation of PAK2" @default.
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• W2076398093 doi "https://doi.org/10.1126/science.276.5318.1571" @default.
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