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• W2076398868 abstract "Abstract Dendritic cells (DCs) have the unique ability to efficiently present T-cell epitopes from exogenous antigens on MHC class I molecules, a process called cross-presentation. In our study we demonstrate that stimulation of monocyte-derived DCs with Toll-like receptor (TLR) ligands differentially affects the uptake and cross-presentation of cellular antigens. Activation of DCs with TLR3 or TLR4 but not with TLR2 or TLR7/8 ligands inhibited phagocytosis of apoptotic tumor cells and resulted in a reduced cross-presentation of pp65-derived T-cell epitopes on MHC class I molecules upon engulfment of cytomegalovirus (CMV)–infected fibroblasts. These results have an important impact on the understanding of the interactions between the immune system and pathogens and the development of vaccination strategies to treat malignant diseases." @default.
• W2076398868 created "2016-06-24" @default.
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• W2076398868 date "2007-01-11" @default.
• W2076398868 modified "2023-10-10" @default.
• W2076398868 title "TLR ligands differentially affect uptake and presentation of cellular antigens" @default.
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• W2076398868 doi "https://doi.org/10.1182/blood-2006-04-015719" @default.
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