Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076402733> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2076402733 endingPage "530" @default.
- W2076402733 startingPage "521" @default.
- W2076402733 abstract "The requirement for co-stimulatory molecules in T-cell stimulation by mitogens and superantigens in the absence of antigen-presenting cells (APC) was investigated. Phytohemagglutinin (PHA) induced interleukin (IL)-2 receptor (IL-2R) expression on purified T-cells, but proliferation occurred only when exogenous IL-2 was added. In contrast, the proliferative response to a pepsin-extracted type 5 M-protein from Streptococcus pyogenes (pep M5), a recently identified superantigen, required signals provided by phorbol 12-myristate 13-acetate (PMA), IL-1 and IL-6. pep M5 alone did not induce IL-2R expression; however, when combined with PMA, IL-1 and IL-6, IL-2R was expressed. Differences were also observed in the response of the leukemic T-cell line, Jurkat, to PHA and pep M5. Soluble PHA, but not pep M5, induced IL-2 production by these cells in the presence of PMA. Cross-linking by its specific antibody or adsorption of pep M5 to microtiter plates was required to activate Jurkat cells. Both PHA and pep M5 induced Ca2+ mobilization in Jurkat cells; however, only PHA induced a rise in intracellular Ca2+ in purified T-cells, whereas pep M5 was unable to induce this activity unless IL-1, IL-6 and PMA were added. Our data provide biochemical evidence that mitogenic and superantigenic stimulation of T-cells is different." @default.
- W2076402733 created "2016-06-24" @default.
- W2076402733 creator A5030225233 @default.
- W2076402733 creator A5056386912 @default.
- W2076402733 creator A5068812282 @default.
- W2076402733 creator A5078858810 @default.
- W2076402733 date "1990-01-01" @default.
- W2076402733 modified "2023-09-25" @default.
- W2076402733 title "Differential signal requirements in T-cell activation by mitogen and superantigen" @default.
- W2076402733 cites W1974148619 @default.
- W2076402733 cites W2000692160 @default.
- W2076402733 cites W2004118180 @default.
- W2076402733 cites W2026108503 @default.
- W2076402733 cites W2027306447 @default.
- W2076402733 cites W2032905651 @default.
- W2076402733 cites W2034181842 @default.
- W2076402733 cites W2040020188 @default.
- W2076402733 cites W2049478058 @default.
- W2076402733 cites W2097713397 @default.
- W2076402733 cites W2103320120 @default.
- W2076402733 cites W2115409850 @default.
- W2076402733 cites W2124956623 @default.
- W2076402733 cites W2139245140 @default.
- W2076402733 cites W2142302755 @default.
- W2076402733 cites W2172383460 @default.
- W2076402733 cites W2173828780 @default.
- W2076402733 doi "https://doi.org/10.1016/0898-6568(90)90074-k" @default.
- W2076402733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2081094" @default.
- W2076402733 hasPublicationYear "1990" @default.
- W2076402733 type Work @default.
- W2076402733 sameAs 2076402733 @default.
- W2076402733 citedByCount "15" @default.
- W2076402733 countsByYear W20764027332016 @default.
- W2076402733 countsByYear W20764027332017 @default.
- W2076402733 countsByYear W20764027332021 @default.
- W2076402733 countsByYear W20764027332022 @default.
- W2076402733 crossrefType "journal-article" @default.
- W2076402733 hasAuthorship W2076402733A5030225233 @default.
- W2076402733 hasAuthorship W2076402733A5056386912 @default.
- W2076402733 hasAuthorship W2076402733A5068812282 @default.
- W2076402733 hasAuthorship W2076402733A5078858810 @default.
- W2076402733 hasConcept C147483822 @default.
- W2076402733 hasConcept C153911025 @default.
- W2076402733 hasConcept C179464577 @default.
- W2076402733 hasConcept C19317047 @default.
- W2076402733 hasConcept C203014093 @default.
- W2076402733 hasConcept C2776090121 @default.
- W2076402733 hasConcept C2777371288 @default.
- W2076402733 hasConcept C2778690821 @default.
- W2076402733 hasConcept C2992881475 @default.
- W2076402733 hasConcept C36333154 @default.
- W2076402733 hasConcept C49382859 @default.
- W2076402733 hasConcept C54355233 @default.
- W2076402733 hasConcept C79879829 @default.
- W2076402733 hasConcept C81885089 @default.
- W2076402733 hasConcept C86803240 @default.
- W2076402733 hasConcept C8891405 @default.
- W2076402733 hasConcept C95444343 @default.
- W2076402733 hasConceptScore W2076402733C147483822 @default.
- W2076402733 hasConceptScore W2076402733C153911025 @default.
- W2076402733 hasConceptScore W2076402733C179464577 @default.
- W2076402733 hasConceptScore W2076402733C19317047 @default.
- W2076402733 hasConceptScore W2076402733C203014093 @default.
- W2076402733 hasConceptScore W2076402733C2776090121 @default.
- W2076402733 hasConceptScore W2076402733C2777371288 @default.
- W2076402733 hasConceptScore W2076402733C2778690821 @default.
- W2076402733 hasConceptScore W2076402733C2992881475 @default.
- W2076402733 hasConceptScore W2076402733C36333154 @default.
- W2076402733 hasConceptScore W2076402733C49382859 @default.
- W2076402733 hasConceptScore W2076402733C54355233 @default.
- W2076402733 hasConceptScore W2076402733C79879829 @default.
- W2076402733 hasConceptScore W2076402733C81885089 @default.
- W2076402733 hasConceptScore W2076402733C86803240 @default.
- W2076402733 hasConceptScore W2076402733C8891405 @default.
- W2076402733 hasConceptScore W2076402733C95444343 @default.
- W2076402733 hasIssue "6" @default.
- W2076402733 hasLocation W20764027331 @default.
- W2076402733 hasLocation W20764027332 @default.
- W2076402733 hasOpenAccess W2076402733 @default.
- W2076402733 hasPrimaryLocation W20764027331 @default.
- W2076402733 hasRelatedWork W1545383778 @default.
- W2076402733 hasRelatedWork W2025159433 @default.
- W2076402733 hasRelatedWork W2036461385 @default.
- W2076402733 hasRelatedWork W2071677096 @default.
- W2076402733 hasRelatedWork W2076402733 @default.
- W2076402733 hasRelatedWork W2078867967 @default.
- W2076402733 hasRelatedWork W2103274533 @default.
- W2076402733 hasRelatedWork W2143167013 @default.
- W2076402733 hasRelatedWork W2153901715 @default.
- W2076402733 hasRelatedWork W2160354338 @default.
- W2076402733 hasVolume "2" @default.
- W2076402733 isParatext "false" @default.
- W2076402733 isRetracted "false" @default.
- W2076402733 magId "2076402733" @default.
- W2076402733 workType "article" @default.