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• W2076404162 abstract "Background & Aims: Patients with cirrhosis are characterized by a reduced splanchnic vascular resistance and a hyporeactivity to adrenergic vasoconstrictors. So far, their adrenergic splanchnic vascular responsiveness has not been evaluated in vitro. We compared responses to α1- and β2-adrenoceptor stimulation of hepatic arteries and portal veins of patients with cirrhosis undergoing transplantation with those of organ donors. Methods: Isometric contractions of endothelium-denuded vessel rings were induced cumulatively by methoxamine and relaxations by isoproterenol. Results are expressed as percentage of the contraction obtained by 85 mmol/L KCl or of the relaxation obtained by 100 μmol/L papaverine, respectively. Results: Maximal methoxamine-induced contractions were reduced in cirrhotic hepatic arteries (cirrhosis, 51.8% ± 6.8%; donor, 89.9% ± 6.6%; P < 0.01) and portal veins (cirrhosis, 49.2% ± 6.4%; donor, 94.0% ± 5.3%; P < 0.01). In cirrhosis, isoproterenol induced a less marked relaxation of hepatic arteries (cirrhosis, 46.6% ± 3.2%; donor, 100.3% ± 4.4%; P < 0.01) but an increased relaxation of portal veins (cirrhosis, 41.9% ± 6.2%; donor, 26.2% ± 2.8%; P < 0.01). Conclusions: In cirrhosis, endothelium-free hepatic arteries are hyporeactive to α1- and β2-adrenoceptor agonists, and portal veins are hyporeactive to α1- but hyperreactive to β2-adrenoceptor agonists. These findings support the in vivo findings of a hyporesponsiveness to adrenergic vasoconstrictors in patients with cirrhosis.GASTROENTEROLOGY 1999;116:387-393" @default.
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• W2076404162 date "1999-02-01" @default.
• W2076404162 modified "2023-10-16" @default.
• W2076404162 title "Altered adrenergic responsiveness of endothelium-denuded hepatic arteries and portal veins in patients with cirrhosis" @default.
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• W2076404162 doi "https://doi.org/10.1016/s0016-5085(99)70136-8" @default.
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