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• W2076407117 abstract "Incidence and prevalence of asthma have increased in recent decades with the underlying reason remaining unclear. The majority of cases of persistent wheezing and asthma begin in early childhood, which primarily defines the individual's respiratory health throughout their lifetime. Nearly half of wheezing preschoolers “outgrow” their symptoms and commonly demonstrate reduced pulmonary function early on. Their pulmonary function typically improves by age 6 years but not to the levels of normal function as seen in those children that never wheezed. Inhaled corticosteroids are the primary first-line therapy for asthma, helping physicians gain control of clinical symptoms. However, research is demonstrating that these therapies do not prevent the development of airway dysfunction later in life. In fact, asthma is now described as a risk factor for chronic obstructive pulmonary disease. Clearly, the pathogenic mechanisms have not been identified in this process, and thus research needs to target this very important topic. A combination of genetic and environmental factors is probably the cause. To impact prevalence, morbidity and mortality, research needs to address whether steroid insensitivity is playing a role or are there other physiological mechanisms playing a role." @default.
• W2076407117 created "2016-06-24" @default.
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• W2076407117 date "2010-01-01" @default.
• W2076407117 modified "2023-09-25" @default.
• W2076407117 title "Childhood asthma in adults" @default.
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• W2076407117 doi "https://doi.org/10.1515/ijdhd.2010.023" @default.
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