FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076408575> ?p ?o ?g. }

• W2076408575 endingPage "779" @default.
• W2076408575 startingPage "770" @default.
• W2076408575 abstract "In this work, solid lipid nanoparticles loaded with cucurbitacin B (Cu B-SLNs) were prepared. It was found that the concentration of poloxamer 188 and soybean lecithin had effects on the mean particle size and size distribution. The zeta potentials were around −33 mV. In vitro release studies showed a sustained release after a burst release. Internalization of Cu B into HepG2 cells could be enhanced by the encapsulation of SLN matrix. The IC50 values of Cu B-SLNs were lower than that of Cu B solution. Both free Cu B and Cu B-SLNs had effectively inhibited the tumor growth and displayed a dose-dependent anti-tumor efficacy. Cu B-SLNs at a dose of 0.11 mg/kg produced the greatest anti-tumor effects (53.3%), which was significant higher than Cu B solution (31.5%, p < 0.05). Cu B-SLNs showed a longer MRT in vivo. The AUC of Cu B-SLNs for tumor increased 3.5 –fold when compared to Cu B solution. The targeting efficiency of Cu B-SLNs was 1.94 times higher in liver as compared to that of Cu B solution. These results indicated that Cu-B SLNs could passively target the tumor with EPR effect, improve the therapeutic efficacy of Cu B, and reduce the doses." @default.
• W2076408575 created "2016-06-24" @default.
• W2076408575 creator A5003322678 @default.
• W2076408575 creator A5043131666 @default.
• W2076408575 creator A5043289848 @default.
• W2076408575 creator A5048226529 @default.
• W2076408575 creator A5089240018 @default.
• W2076408575 date "2012-07-16" @default.
• W2076408575 modified "2023-09-25" @default.
• W2076408575 title "Preparation, characterization, cellular uptake and evaluation<i>in vivo</i>of solid lipid nanoparticles loaded with cucurbitacin B" @default.
• W2076408575 cites W1552589960 @default.
• W2076408575 cites W1579046626 @default.
• W2076408575 cites W1767611922 @default.
• W2076408575 cites W1963800833 @default.
• W2076408575 cites W1964649030 @default.
• W2076408575 cites W1967326563 @default.
• W2076408575 cites W1968414280 @default.
• W2076408575 cites W1971842719 @default.
• W2076408575 cites W1982974605 @default.
• W2076408575 cites W1983223375 @default.
• W2076408575 cites W1987287476 @default.
• W2076408575 cites W1989858223 @default.
• W2076408575 cites W1990163407 @default.
• W2076408575 cites W2002150064 @default.
• W2076408575 cites W2002516695 @default.
• W2076408575 cites W2007893172 @default.
• W2076408575 cites W2014066468 @default.
• W2076408575 cites W2016258885 @default.
• W2076408575 cites W2017323111 @default.
• W2076408575 cites W2020882358 @default.
• W2076408575 cites W2020915539 @default.
• W2076408575 cites W2028258807 @default.
• W2076408575 cites W2028417237 @default.
• W2076408575 cites W2028761028 @default.
• W2076408575 cites W2029462442 @default.
• W2076408575 cites W2031185391 @default.
• W2076408575 cites W2033713320 @default.
• W2076408575 cites W2037048276 @default.
• W2076408575 cites W2049511402 @default.
• W2076408575 cites W2055449190 @default.
• W2076408575 cites W2057589352 @default.
• W2076408575 cites W2064566941 @default.
• W2076408575 cites W2065302847 @default.
• W2076408575 cites W2070070670 @default.
• W2076408575 cites W2074037814 @default.
• W2076408575 cites W2086369979 @default.
• W2076408575 cites W2086736463 @default.
• W2076408575 cites W2093624389 @default.
• W2076408575 cites W2095016306 @default.
• W2076408575 cites W2115666726 @default.
• W2076408575 cites W2126020016 @default.
• W2076408575 cites W2142869757 @default.
• W2076408575 cites W2145017051 @default.
• W2076408575 cites W2156368993 @default.
• W2076408575 cites W2171083652 @default.
• W2076408575 cites W2171638781 @default.
• W2076408575 cites W3011556 @default.
• W2076408575 cites W348674655 @default.
• W2076408575 doi "https://doi.org/10.3109/03639045.2012.702348" @default.
• W2076408575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22794139" @default.
• W2076408575 hasPublicationYear "2012" @default.
• W2076408575 type Work @default.
• W2076408575 sameAs 2076408575 @default.
• W2076408575 citedByCount "27" @default.
• W2076408575 countsByYear W20764085752013 @default.
• W2076408575 countsByYear W20764085752014 @default.
• W2076408575 countsByYear W20764085752015 @default.
• W2076408575 countsByYear W20764085752016 @default.
• W2076408575 countsByYear W20764085752017 @default.
• W2076408575 countsByYear W20764085752019 @default.
• W2076408575 countsByYear W20764085752020 @default.
• W2076408575 countsByYear W20764085752021 @default.
• W2076408575 countsByYear W20764085752022 @default.
• W2076408575 countsByYear W20764085752023 @default.
• W2076408575 crossrefType "journal-article" @default.
• W2076408575 hasAuthorship W2076408575A5003322678 @default.
• W2076408575 hasAuthorship W2076408575A5043131666 @default.
• W2076408575 hasAuthorship W2076408575A5043289848 @default.
• W2076408575 hasAuthorship W2076408575A5048226529 @default.
• W2076408575 hasAuthorship W2076408575A5089240018 @default.
• W2076408575 hasConcept C101335993 @default.
• W2076408575 hasConcept C13965031 @default.
• W2076408575 hasConcept C147789679 @default.
• W2076408575 hasConcept C150903083 @default.
• W2076408575 hasConcept C155672457 @default.
• W2076408575 hasConcept C15920480 @default.
• W2076408575 hasConcept C171250308 @default.
• W2076408575 hasConcept C178790620 @default.
• W2076408575 hasConcept C185592680 @default.
• W2076408575 hasConcept C187530423 @default.
• W2076408575 hasConcept C192562407 @default.
• W2076408575 hasConcept C199529486 @default.
• W2076408575 hasConcept C202751555 @default.
• W2076408575 hasConcept C207001950 @default.
• W2076408575 hasConcept C2779564620 @default.
• W2076408575 hasConcept C2780306666 @default.
• W2076408575 hasConcept C43617362 @default.
• W2076408575 hasConcept C521977710 @default.

• next